百草枯的神经免疫毒性研究进展

Research progress on neuro-immune toxicity of paraquat

摘要: 百草枯是一种被广泛使用的中等毒性除草剂。现有流行病学资料显示，长期低剂量接触百草枯可增加人群帕金森病等中枢神经系统退行性疾病的风险。本研究将对百草枯引起中枢神经系统损伤过程中所涉及到的免疫反应研究进展进行系统性综述，包括：百草枯可以诱导中枢神经系统免疫紊乱，导致神经炎症的发生；神经炎症的发生发展与百草枯诱导的神经系统损伤有关；百草枯引起的神经炎症可能受多重因子网络的调控。以期为深入研究百草枯的神经免疫毒作用机制及后期药物干预提供理论依据。

Abstract: Paraquat is a widely used herbicide with moderate toxicity to human. According to available epidemiological data, paraquat can in crease the risk of central nervous system degenerative diseases such as Parkinson's disease by chronic low-dose administration. In this paper, a systematic review summarized the immune response involved in central nervous system injury induced by paraquat, in cluding immune disorder of central nervous system and neuroinflammation induced by paraquat, neuroinflammation development associated with neurological damage induced by paraquat, and neuroinflammation induced by paraquat and regulated by multiple factor networks, aiming to provide a theoretical basis for further study of the mechanism of neuro-immune toxicity of paraquat and future drug intervention.