吡虫啉暴露及其遗传毒性研究进展

Research progress on imidacloprid exposure and genotoxity

摘要: 吡虫啉是新烟碱类杀虫剂的典型代表，具有杀虫谱广、对哺乳动物低毒的特点，在世界范围内广泛应用。吡虫啉在环境中广泛存在且可在人体内检出，其潜在毒性（特别是遗传毒性）已经引起了人们的关注。中国是世界上最大的吡虫啉生产与出口国，年产量约占全球总产量的三分之二。然而我国在吡虫啉暴露方面的数据较少，鉴于吡虫啉的广泛存在及其可能的遗传毒性影响，未来研究应着重关注其对人群的遗传损伤及其机制探究。

Abstract: Imidacloprid, a typical neonicotinoid insecticide, has the characteristics of broad-spectrum insect control and low toxicity to mammals, and therefore is widely used. Now imidacloprid exists in both environment and human body, and its potential toxic effects, particularly genetic toxicity, have raised great concern. China is the largest country producing and exporting imidacloprid, and its annual output accounts for about two-thirds of the global total production. However, few data report the human exposure to imidacloprid in China. Given the widespread presence of imidacloprid and its potential genetic toxicity, future research should focus on its genetic damage to human being and relevant mechanism