美国FDA禁止的抗菌皂成分安全性评价资料概述

Summary of Safety Evaluation Data of Selected Active Compounds in Antibacterial Soap Banned by USFDA

  • 摘要: USFDA于2016年9月发布消息,禁止抗菌皂中使用三氯生和三氯卡班等19种化合物,主要是因为厂家不能按时提供相关化合物安全性和有效性资料。这19种化合物中三氯卡班、三氯生和苯酚等7种化合物在国内已经有较多的毒理学研究资料,4-己基间苯二酚、氯化苄乙氧铵、壬基酚聚氧乙烯醚三种化合物有较少的毒理学资料,剩下的化合物尚且缺乏毒理学资料。本篇综述简单介绍这些类化合物的基本性质和已有的毒理学资料。

     

    Abstract: In September 2016, USFDA announced a ban on 19 compounds in antibacterial soap, such as triclosan and triclocarban, mainly because manufacturers cannot provide the safety and effectiveness data of those compounds. To our knowledge, 7 compounds including triclocarban, triclosan, and phenol have been more studied in China; 4-hexylresorcinol, methyl benzethonium chloride, and nonylphenoxypoly (ethyleneoxy) ethanoliodine have a few toxicological profiles availbale; and the rest are poorly understood. This article summarized the toxicological information of these selected compounds.

     

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