Abstract: Atmospheric pollutants such as fine particulate matter (PM_2.5), dust, and rare earth particles are critical environmental risk factors that may induce cardiovascular system diseases and respiratory system diseases. It is known that the potential mechanism of injury to lung tissue by particulate matters may include inflammation, oxidative stress, and c-jun N-termminal kinase (JNK) signaling pathway. This review summarized the relationship between JNK signal pathway and PM_2.5, dust, rare earth particles. New molecular target for treatment of relevant diseases could be identified by understanding the specific cell damage mechanism of JNK signal pathway.