Abstract: Work-related musculoskeletal disorders (WMSDs) are a leading cause of worker absenteeism, disability, and wage loss. To mitigate WMSDs, many countries and organizations have established classification systems; however, significant discrepancies persist due to the lack of a unified consensus. China’s newly revised Classification and Catalogue of Occupational Diseases will take effect in August 2025, marking the first inclusion of WMSDs as a statutory occupational disease category, encompassing carpal tunnel syndrome and bursitis. On the occasion of this updated list, this paper reviewed the global status of WMSDs and compared their classification frameworks across major countries and regions. The special column on WMSDs was organized to address the epidemiological trends, risk factor identification, and assessment methodologies in China, aiming to provide scientific foundations for the prevention and control of WMSDs.