峰度对非稳态噪声所致职业性听力损失的作用阈值

Threshold of kurtosis on occupational hearing loss associated with non-steady noise

  • 摘要:
    背景 峰度(反映噪声时域结构)是评估噪声性听力损失(NIHL)的有效参数,其作用阈值尚不清楚。
    目的 探寻峰度起作用的能量范围,和在该能量范围下的峰度所致NIHL的作用阈值。
    方法 采用横断面分析,选择制造业4631名噪声接触工人为研究对象,收集每个研究对象的听力损失情况和噪声暴露数据。采用logistic回归模型建立剂量反应关系,探寻能量起作用的范围,利用限制性立方样条模型分析不同8 h等效声级(LEX,8 h)下峰度与噪声听力障碍(NIHI)和高频噪声性听力损失(HFNIHL)的剂量反应关系曲线,分析峰度作用阈值。
    结果 logistic回归模型分析结果显示:稳态噪声中随着LEX,8 h增加,NIHI和HFNIHL的患病率升高;非稳态噪声中LEX,8 h在80~100 dB(A)时,峰度为危险因素,随着峰度的增大,听力损失患病风险增加(P < 0.05)。限制性立方样条模型显示:非稳态噪声LEX,8 h在小于80 dB(A)和大于100 dB(A)时,峰度与NIHI或HFNIHL患病风险之间无关系;LEX,8 h在80~100 dB(A)范围内,峰度与NIHI或HFNIHL患病风险之间存在非线性剂量反应关系(P < 0.001),且大于28.08的峰度能对NIHI或HFNIHL起作用。
    结论 非稳态噪声水平在80~100 dB(A)范围内,峰度对NIHL的作用阈值为28.08。该作用阈值需进一步验证。

     

    Abstract:
    Background Kurtosis reflecting noise's temporal structure is an effective metric for evaluating noise-induced hearing loss (NIHL), and its threshold is still unclear.
    Objective To explore the energy range of kurtosis and the threshold of NIHL induced by kurtosis in this energy range
    Methods Using cross-sectional design, 4631 noise-exposed workers in manufacturing industry were selected. The hearing loss and noise exposure data of each worker were collected. Logistic regression model was used to establish the dose-response relationship between noise exposure and hearing loss and estimate the range of energy effects. Restricted cubic spline model was utilized to analyze the dose-response relationship curves of kurtosis to noise-induced hearing loss (NIHI) and high-frequency noise-induced hearing loss (HFNIHL) under different 8 h equivalent sound levels (LEX,8 h), as well as to estimate the kurtosis effect threshold.
    Results The logistic regression model analysis showed that the prevalence of NIHI and HFNIHL increased significantly with increase of LEX,8 h for steady noise; when LEX,8 h of non-steady noise was 80-100 dB(A), the risk of hearing loss increased with an increase in kurtosis (P<0.05). The restricted cubic spline model showed that when LEX,8 h of non-steady noise was 0-80 dB(A) or >100 dB(A), there was no significant relationship between kurtosis and NIHI or HFNIHL. When LEX,8 h was 80-100 dB(A), there was a significant nonlinear dose-response relationship between kurtosis and NIHL or HFNIHL (P <0.001), and kurtosis > 28.08 exerted effect in elevating NIHI or HFNIHL.
    Conclusion The effect threshold of kurtosis on NIHL is 28.08 when non-steady noise levels are in the range of 80-100 dB(A). The effect threshold of kurtosis needs further verification.

     

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