双酚类物质雌性生殖毒性研究进展

Research progress on female reproductive toxicity of bisphenols

  • 摘要: 双酚类物质(BPs)因广泛应用于食品包装、个人护理产品和塑料制品,普遍存在于人类生活和工作环境中而备受关注。BPs作为内分泌干扰物,通过与雌激素受体结合,激活或抑制与生殖功能相关基因的表达,干扰内分泌系统的正常功能,对雌性生殖系统产生毒性作用。本文从对雌性生殖器官的影响、相关的生殖系统疾病的发生及毒性作用机制三个方面综述了双酚A(BPA)、双酚S(BPS)、双酚F(BPF)对雌性生殖功能的影响,重点阐述了对卵巢功能、子宫形态与功能、输卵管功能的影响以及与多囊卵巢综合征、子宫内膜异位症、子痫及流产之间的相关性,并对BPs暴露的毒性机制进行了总结,以期为今后BPs对雌性生殖系统的影响研究及其潜在健康风险评估和预防措施提供科学依据。

     

    Abstract: Bisphenols (BPs) are extensively used in food packaging, personal care products, and plastics, making them prevalent in both living and working environments, which has raised significant concern. As endocrine-disrupting chemicals, BPs exert toxic effects on the female reproductive system by binding to estrogen receptors, thereby activating or inhibiting the expression of genes related to reproductive functions, which disrupts the normal function of the endocrine system. This paper reviewed the effects of bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF) on female reproductive function, focusing on three key aspects: the effects on the female reproductive organs, the occurrence of associated reproductive disorders, and the mechanisms of toxicity. Specifically, this review highlighted the effects on ovarian function, uterine morphology and function, and fallopian tube function, as well as their correlation with polycystic ovary syndrome, endometriosis, miscarriage, and eclampsia. Additionally, the toxic mechanisms of BPs exposure were summarized, providing a scientific basis for future research on the impact of BPs on the female reproductive system, as well as for the assessment of potential health risks and the development of preventive measures.

     

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