我国食品全氟化合物的污染及人群膳食暴露风险评估研究进展

Per- and polyfluoroalkyl substances in China: Food contamination and human dietary exposure risk assessment

  • 摘要: 全氟化合物(PFAS)是一类高度氟化的有机物,属于环境内分泌干扰物。人群普遍暴露于PFAS,而膳食是最主要的暴露来源。已有大量研究检测了我国多种食品中PFAS的污染水平,并在此基础上对人群进行了PFAS的膳食暴露风险评估。本文系统梳理既往国内相关研究,以反映该领域的研究现状,总结我国各类食品中PFAS的污染情况和人群PFAS膳食暴露水平,并对未来研究做出展望。现有研究主要关注了水产品、肉类、蛋类、奶类和植物性食物等食品中全氟烷基羧酸(PFCA)、全氟烷基磺酸(PFSA)和氯化多氟烷基醚磺酸(Cl-PFESA)三类PFAS的污染及相应的人群暴露风险。动物性食品中,水产品、蛋类和肉类污染较为严重,奶类的污染水平最低。不少研究发现氟化工业园(FIP)附近的植物性食品PFAS污染水平较高,但是非FIP地区植物性食物的PFAS污染水平远低于动物性食品。多项评估均表明FIP附近地区居民(相对于非FIP地区居民)的PFAS膳食暴露水平较高,儿童的暴露水平是成人的数倍,说明这两类人群具有更高的暴露倾向。研究通常采用危害商(HQ)或危害指数(HI)来量化人群膳食暴露风险,但由于不同研究纳入评估的食物种类和选取的健康指导值(HBGV)不尽相同,风险评估结果不具有可比性。参考2018年欧洲食品安全局制定的HBGV,我国部分地区(尤其是FIP附近地区)居民的PFAS膳食暴露水平存在健康风险。后续对于PFAS的膳食暴露风险评估可参考既往研究情况,合理选择纳入评估的食物和PFAS种类,同时应进一步加强评估的全面性和准确性,以为我国人群的PFAS暴露风险管控提供科学依据。

     

    Abstract: Per- and polyfluoroalkyl substances (PFAS) are a class of highly fluorinated organic compounds that belong to environmental endocrine disruptors. People are ubiquitously exposed to PFAS, with diet being the primary source of exposure. Numerous studies detected PFAS contamination in various foods in China, followed by dietary exposure risk assessment of PFAS in the population. This article systematically reviewed previous domestic research to reflect the current research status, summarize the contamination of PFAS in various types of food in China and the dietary exposure level of PFAS in the population, and put forward prospects for future research. Previous research mainly focused on the contamination of three types of PFAS, namely perfluoroalkyl carboxylic acid (PFCA), perfluoroalkyl sulfonic acid (PFSA), and chlorinated polyfluoroalkyl ether sulfonic acid (Cl-PFESA), in aquatic products, meat, eggs, dairy products, and plant-based foods, as well as the corresponding population exposure risks. Among animal origin foods, aquatic products, eggs, and meat were more severely contaminated, while dairy products were at the lowest level of contamination. Many studies reported high levels of PFAS contamination in plant origin foods near fluorochemical industrial parks (FIP) . However, the PFAS contamination level of plant origin foods in non-FIP areas was much lower than that of animal origin foods. Many studies demonstrated higher dietary exposure to PFAS in residents in proximity to FIP than that in non-FIP areas, and children's exposure was several times greater than that of adults, indicating a higher susceptibility to PFAS exposure in these two populations. The included studies typically used hazard quotient (HQ) or hazard index (HI) to quantify the risk of dietary exposure in populations, but the risk assessment results were not comparable due to differences in the types of food evaluated and the health-based guidance value (HBGV) selected across different studies. According to the HBGV established by the European Food Safety Authority in 2018, there are health risks associated with PFAS dietary exposure among residents in some regions of China, especially those near FIP. For subsequent dietary exposure risk assessments of PFAS, previous research can be referenced to make informed choices about the foods and PFAS types to be included in the assessment. Furthermore, it is crucial to enhance the comprehensiveness and accuracy of these assessments to provide a scientific basis for managing PFAS exposure risks among the Chinese population.

     

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