职业危害因素暴露与男性煤矿从业人员促甲状腺激素与甲状腺激素水平的关联

戴颖诗, 陈颖君, 罗颖琪, 刘燕辉, 蒋柳权, 杨帆, 刘改生, 陈青松

戴颖诗, 陈颖君, 罗颖琪, 刘燕辉, 蒋柳权, 杨帆, 刘改生, 陈青松. 职业危害因素暴露与男性煤矿从业人员促甲状腺激素与甲状腺激素水平的关联[J]. 环境与职业医学, 2025, 42(4): 459-466. DOI: 10.11836/JEOM24376
引用本文: 戴颖诗, 陈颖君, 罗颖琪, 刘燕辉, 蒋柳权, 杨帆, 刘改生, 陈青松. 职业危害因素暴露与男性煤矿从业人员促甲状腺激素与甲状腺激素水平的关联[J]. 环境与职业医学, 2025, 42(4): 459-466. DOI: 10.11836/JEOM24376
DAI Yingshi, CHEN Yingjun, LUO Yingqi, LIU Yanhui, JIANG Liuquan, YANG Fan, LIU Gaisheng, CHEN Qingsong. Thyroid-stimulating hormone and thyroid hormone levels in association with occupational hazards in male coal miners[J]. Journal of Environmental and Occupational Medicine, 2025, 42(4): 459-466. DOI: 10.11836/JEOM24376
Citation: DAI Yingshi, CHEN Yingjun, LUO Yingqi, LIU Yanhui, JIANG Liuquan, YANG Fan, LIU Gaisheng, CHEN Qingsong. Thyroid-stimulating hormone and thyroid hormone levels in association with occupational hazards in male coal miners[J]. Journal of Environmental and Occupational Medicine, 2025, 42(4): 459-466. DOI: 10.11836/JEOM24376

职业危害因素暴露与男性煤矿从业人员促甲状腺激素与甲状腺激素水平的关联

基金项目: 

广州市科技计划项目(2025A03J3722)

详细信息
    作者简介:

    戴颖诗(1998—),女,硕士生;E-mail:daiyingshi729@163.com

    通讯作者:

    刘改生,E-mail:xszfslgs@163.com

    陈青松,E-mail:qingsongchen@aliyun.com

  • 中图分类号: R13

Thyroid-stimulating hormone and thyroid hormone levels in association with occupational hazards in male coal miners

Funds: 

This study was funded.

More Information
  • 摘要:
    背景

    甲状腺激素对正常发育至关重要,也是生理系统正常运作所必需的。目前关于甲状腺的研究主要聚焦在生活行为因素对甲状腺功能异常的影响,聚焦甲状腺激素水平的影响因素的探究较少,尤其是职业危害因素,应予以进一步研究。

    目的

    调查职业危害因素暴露与男性煤矿从业人员促甲状腺激素(TSH)和甲状腺激素水平的关联。

    方法

    采用横断面设计的研究方法,选取2023年于西山煤电(集团)有限责任公司职业病防治所参与健康体检、符合纳入排除标准的12564名职业工人作为研究对象。采用自行设计的问卷收集所有研究对象的基本信息、职业史、生活行为习惯等信息,通过职业健康体检和工作场所职业危害因素检测资料,获取研究对象的身高、体重、甲状腺功能检查结果和职业危害因素暴露情况。本研究采用广义线性回归分析各职业危害因素与TSH和甲状腺激素水平的关联。

    结果

    12564名男性煤矿从业人员三碘甲腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)和TSH水平的MP25P75)分别为1.16(1.03,1.29)ng·mL−1、7.70(6.70,8.90)μg·dL−1、3.63(3.40,3.84)pg·mL−1、1.19(1.08,1.30)ng·dL−1和1.93(1.36,2.78)μIU·mL−1。甲状腺激素异常总检出率为2.83%,其中亚临床甲状腺减退症的患病率最高(1.83%),其次为甲状腺功能亢进症(0.37%)、甲状腺功能减退症(0.32%)、亚临床甲状腺功能亢进症(0.31%)。调整混杂因素后,广义线性回归模型显示,长工时工作人群的T3、FT3水平更高,β(95%CI)分别为0.011(0.003~0.019)、0.038(0.019~0.057);夜班工作人群的TSH水平升高,而FT4水平降低,β(95%CI)分别为0.171(0.016~0.326)、−0.012(−0.019~−0.006);煤尘暴露人群的T3、T4水平降低,β(95%CI)分别为−0.022(−0.037~−0.008)、−0.320(−0.434~−0.207);噪声暴露人群的T4、FT4水平降低,β(95%CI)分别为−0.102(−0.166~−0.038)、−0.020(−0.027~−0.013)。

    结论

    煤矿从业人员TSH与甲状腺激素水平基本处于正常值参考范围内,异常率较低。长工时工作、夜班工作、煤尘、噪声等职业危害因素与男性煤矿从业人员TSH和甲状腺激素水平相关。煤矿企业应合理安排工作时间、科学优化夜班排班制度、加强煤尘和噪声防护措施,促进职业健康,保障煤矿从业人员的身体健康。

     

    Abstract:
    Background

    Thyroid hormones are crucial for development and proper functioning of human physiological systems. Current research on the thyroid mainly focuses on the impacts of lifestyle factors on thyroid dysfunction, while less attention is paid to the factors affecting thyroid hormone levels, especially occupational hazards, which warrants further investigation.

    Objective

    To investigate the associations between occupational hazard exposure and thyroid-stimulating hormone (TSH) and thyroid hormone levels in male coal mine workers.

    Methods

    A cross-sectional study design was adopted. A total of 12564 workers who participated in the occupational health check-ups at the Xishan Coal Electricity (Group) Corporation Occupational Disease Prevention and Control Institute in 2023 and met the inclusion and exclusion criteria were selected as research subjects. A self-designed electronic questionnaire was used to collect basic information, occupational history, and lifestyle habits of all study subjects. Height, weight, thyroid function test results, and occupational hazard exposure of the study subjects were obtained through occupational health examinations and routine workplace occupational hazard detection records. Generalized linear regression was used to analyze the associations between occupational hazard exposure and the levels of TSH and thyroid hormones.

    Results

    The median (P25, P75) levels of triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4), and TSH in the included 12564 male coal mine workers were 1.16 (1.03, 1.29) ng·mL−1, 7.70 (6.70, 8.90) μg·dL−1, 3.63 (3.40, 3.84) pg·mL−1, 1.19 (1.08, 1.30) ng·dL−1, and 1.93 (1.36, 2.78) μIU·mL−1, respectively. The overall abnormality rate of thyroid hormones was 2.83%, with the highest rate for subclinical hypothyroidism (1.83%), followed by hyperthyroidism (0.37%), hypothyroidism (0.32%), and subclinical hyperthyroidism (0.31%). After adjustment for confounding factors, the generalized linear regression model showed that long working hours were associated with higher levels of T3 and FT3, with β (95%CI) values of 0.011 (0.003, 0.019) and 0.038 (0.019, 0.057) respectively. Night shift work was linked to increased TSH levels and decreased FT4 levels, with β (95%CI) values of 0.171 (0.016, 0.326) and −0.012 (−0.019, −0.006) respectively. Coal dust exposure was associated with decreased levels of T3 and T4, with β (95%CI) values of −0.022 (−0.037, −0.008) and −0.320 (−0.434, −0.207) respectively. Noise exposure was related to decreased levels of T4 and FT4, with β (95%CI) values of −0.102 (−0.166, −0.038) and −0.020 (−0.027, −0.013) respectively.

    Conclusion

    The TSH and thyroid hormone levels of coal miners are mostly within the normal reference ranges, with a low abnormality rate. Long work hours, night shift work, coal dust, and noise are associated with the levels of TSH and thyroid hormone levels in the male miners. Coal companies should reasonably arrange working hours, optimize the night shift scheduling system, and enhance protection against coal dust and noise to promote occupational health and safeguard the physical health of miners.

     

  • 表  1   男性煤矿从业人员不同人口学特征组间TSH和甲状腺激素水平的比较[n=12564MP25P75)]

    Table  1   Comparison of TSH and thyroid hormone levels in male coal miners grouped by demographic characteristics [n=12564, M (P25, P75)]

    人口学特征 n(%) T3/(ng·mL−1) T4/(μg·dL−1) FT3/(pg·mL−1) FT4/(ng·dL−1) TSH/(μIU·mL−1)
    民族
     汉族 12482(99.35) 1.16(1.03,1.29) 7.70(6.70,8.90) 3.63(3.40,3.84) 1.19(1.08,1.30) 1.93(1.08,2.78)
     其他民族 82(0.65) 1.13(0.94,1.24) 7.55(5.90,8.83) 3.66(3.42,3.89) 1.23(1.12,1.31) 1.97(1.32,2.75)
     Z −2.234 −1.462 −1.112 −1.59 −0.104
     P 0.025 0.144 0.266 0.112 0.917
    BMI
     低体重 171(1.36) 1.10(0.98,1.24) 8.00(6.98,9.40) 3.51(3.25,3.78) 1.21(1.11,1.31) 1.79(1.33,2.59)
     正常 3822(30.42) 1.14(1.02,1.27) 7.80(6.70,9.00) 3.61(3.38,3.81) 1.19(1.08,1.30) 1.87(1.31,2.68)
     超重 5487(43.67) 1.15(1.03,1.28) 7.60(6.60,8.80) 3.63(3.40,3.84) 1.19(1.08,1.30) 1.94(1.36,2.80)
     肥胖 3084(24.55) 1.18(1.05,1.32) 7.75(6.70,9.00) 3.66(3.42,3.87) 1.19(1.09,1.30) 2.03(1.43,2.88)
     H 80.606 34.377 51.534 3.424 47.138
     P <0.001 <0.001 <0.001 0.331 <0.001
    教育程度
     小学及以下 139(1.11) 1.20(1.07,1.32) 7.80(6.60,9.10) 3.53(3.31,3.81) 1.14(1.05,1.22) 1.82(1.21,2.85)
     初中 1533(12.20) 1.16(1.03,1.29) 7.60(6.40,8.70) 3.56(3.32,3.78) 1.14(1.05,1.25) 1.88(1.31,2.74)
     高中/中专 4146(33.00) 1.18(1.05,1.31) 7.70(6.60,8.90) 3.64(3.42,3.85) 1.17(1.07,1.29) 1.94(1.36,2.81)
     大专/本科及以上 6746(53.69) 1.14(1.02,1.27) 7.80(6.70,8.90) 3.64(3.40,3.85) 1.21(1.11,1.32) 1.94(1.37,2.77)
     H 58.339 20.375 71.745 292.439 4.673
     P <0.001 <0.001 <0.001 <0.001 0.197
    每月人均收入/元
     ≤3000 5259(41.86) 1.16(1.03,1.30) 7.70(6.70,8.90) 3.62(3.39,3.84) 1.18(1.08,1.30) 1.93(1.36,2.77)
     3001~6000 4592(36.55) 1.15(1.02,1.28) 7.70(6.70,8.90) 3.64(3.40,3.84) 1.19(1.09,1.31) 1.93(1.36,2.76)
     6001~10000 1946(15.49) 1.17(1.04,1.30) 7.70(6.60,8.90) 3.63(3.41,3.84) 1.18(1.08,1.30) 1.96(1.35,2.83)
     ≥10000 767(6.10) 1.15(1.02,1.29) 7.70(6.70,9.00) 3.64(3.40,3.86) 1.19(1.09,1.31) 1.92(1.34,2.76)
     H 7.829 0.838 3.907 18.558 1.096
     P 0.050 0.840 0.272 <0.001 0.778
    婚姻状况
     未婚 818(6.51) 1.15(1.02,1.27) 7.90(6.80,8.90) 3.65(3.44,3.86) 1.22(1.11,1.32) 2.09(1.45,2.94)
     已婚 11309(90.01) 1.16(1.03,1.29) 7.70(6.60,8.90) 3.63(3.39,3.84) 1.18(1.08,1.30) 1.93(1.35,2.76)
     其他 437(3.48) 1.16(1.03,1.30) 7.80(6.80,8.90) 3.58(3.36,3.83) 1.20(1.09,1.33) 1.90(1.38,2.89)
     H 1.199 3.899 10.508 33.825 10.313
     P 0.549 0.142 0.005 <0.001 0.006
    吸烟
     否 2416(19.23) 1.12(0.99,1.24) 7.60(6.50,8.70) 3.56(3.32,3.81) 1.18(1.08,1.30) 2.10(1.48,3.03)
     已戒烟 3019(24.03) 1.18(1.06,1.31) 7.70(6.70,8.80) 3.65(3.42,3.85) 1.17(1.07,1.28) 2.04(1.41,2.94)
     是 7129(56.74) 1.16(1.03,1.30) 7.80(6.70,9.00) 3.64(3.41,3.85) 1.20(1.09,1.31) 1.84(1.31,2.64)
     H 155.910 32.610 75.878 50.026 137.503
     P <0.001 <0.001 <0.001 <0.001 <0.001
    饮酒
     否 4636(36.90) 1.18(1.05,1.31) 8.00(6.80,9.20) 3.63(3.39,3.84) 1.17(1.08,1.28) 1.91(1.33,2.75)
     已戒酒 580(4.62) 1.17(1.04,1.31) 7.90(6.80,9.10) 3.60(3.37,3.81) 1.18(1.06,1.28) 1.91(1.38,2.84)
     是 7348(58.48) 1.14(1.02,1.27) 7.60(6.50,8.70) 3.63(3.40,3.84) 1.20(1.09,1.31) 2.02(1.41,2.91)
     H 115.492 135.150 4.412 59.926 2.969
     P <0.001 <0.001 0.110 <0.001 0.227
    喝茶
     否 8145(64.83) 1.16(1.03,1.29) 7.80(6.70,8.90) 3.64(3.40,3.85) 1.18(1.08,1.30) 1.94(1.37,2.81)
     是 4419(35.17) 1.15(1.03,1.28) 7.70(6.60,8.90) 3.61(3.39,3.83) 1.20(1.09,1.31) 1.90(1.35,2.73)
     Z −2.606 −1.119 −3.413 −3.947 −2.281
     P 0.009 0.263 0.001 <0.001 0.023
    体育锻炼
     否 10006(64.83) 1.16(1.04,1.30) 7.80(6.70,8.90) 3.64(3.41,3.85) 1.19(1.08,1.30) 1.94(1.35,2.78)
     是 2558(35.17) 1.13(1.00,1.26) 7.60(6.60,8.80) 3.59(3.36,3.82) 1.19(1.08,1.31) 1.93(1.36,2.78)
     Z −7.918 −3.581 −6.027 −1.058 −0.442
     P <0.001 <0.001 <0.001 0.290 0.658
    下载: 导出CSV

    表  2   男性煤矿从业人员不同职业危害因素组间TSH和甲状腺激素水平的比较 [n=12564MP25P75)]

    Table  2   Comparison of TSH and thyroid hormone levels in male coal miners grouped by occupational hazards [n=12564, M (P25, P75)]

    职业危害因素n (%)T3/(ng·mL−1)T4/(μg·dL−1)FT3/(pg·mL−1)FT4/(ng·dL−1)TSH//(μIU·mL−1)
    长工时工作
     否4445(35.38)1.15(1.03,1.29)7.70(6.70,8.90)3.60(3.37,3.82)1.19(1.09,1.31)1.97(1.39,2.83)
     是8119(64.62)1.16(1.03,1.29)7.70(6.60,8.90)3.64(3.41,3.85)1.19(1.08,1.30)1.91(1.34,2.75)
     Z−2.087−0.461−5.364−1.569−2.820
     P0.0370.645<0.0010.1170.005
    夜班工作
     否5766(45.89)1.15(1.03,1.28)7.80(6.70,9.00)3.62(3.39,3.83)1.20(1.10,1.31)1.90(1.35,2.70)
     是6798(54.11)1.16(1.03,1.29)7.70(6.60,8.90)3.64(3.40,3.85)1.18(1.07,1.29)1.96(1.37,2.85)
     Z−1.372−2.758−3.064−8.037−3.292
     P0.1700.0060.002<0.0010.001
    煤尘暴露
     否11560(92.01)1.16(1.03,1.29)7.80(6.70,8.90)3.62(3.39,3.84)1.19(1.09,1.30)1.94(1.36,2.78)
     是1004(7.99)1.15(1.02,1.27)7.40(6.30,8.60)3.69(3.45,3.88)1.16(1.05,1.28)1.89(1.35,2.75)
     Z5.14346.39629.35226.8950.189
     P0.023<0.001<0.001<0.0010.664
    噪声暴露
     否6299(50.14)1.15(1.02,1.28)7.80(6.80,9.00)3.59(3.32,3.82)1.21(1.11,1.32)1.91(1.37,2.72)
     是6265(49.86)1.16(1.03,1.29)7.70(6.60,8.90)3.64(3.41,3.85)1.18(1.08,1.29)1.94(1.35,2.79)
     Z2.39821.49920.55397.2190.052
     P0.122<0.001<0.001<0.0010.820
    下载: 导出CSV

    表  3   职业危害因素与TSH和甲状腺激素水平的关联 [β(95%CI)]

    Table  3   Relationships of occupational hazards with TSH and thyroid hormone levels [β (95%CI)]

    组别 模型1 模型2 模型3
    长工时工作
     T3 0.009(0.001~0.017)* 0.010(0.002~0.018)* 0.011(0.003~0.019)*
     T4 0.017(−0.046~0.080) 0.026(−0.036~0.089) 0.043(−0.020~0.105)
     FT3 0.035(0.018~0.053)* 0.036(0.019~0.054)* 0.038(0.019~0.057)*
     FT4 −0.004(−0.011~0.003) −0.005(−0.011~0.002) −0.003(−0.010~0.004)
     TSH −0.017(−0.172~0.139) −0.006(−0.161~0.150) −0.022(−0.178~0.135)
    夜班工作
     T3 0.003(−0.005~0.010) −0.001(−0.009~0.006) −0.002(−0.010~0.006)
     T4 −0.083(−0.143~−0.023)* −0.092(−0.152~−0.032)* −0.058(−0.120~0.004)
     FT3 0.017(0.001~0.034)* 0.016(−0.001~0.032) 0.006(−0.013~0.025)
     FT4 −0.021(−0.028~−0.015)* −0.017(−0.023~−0.010)* −0.012(−0.019~−0.006)*
     TSH 0.190(0.040~0.339)* 0.176(0.025~0.327)* 0.171(0.016~0.326)*
    煤尘
     T3 −0.018(−0.032~−0.004)* −0.020(−0.034~−0.006)* −0.022(−0.037~−0.008)*
     T4 −0.399(−0.509~−0.288)* −0.397(−0.507~−0.287)* −0.320(−0.434~−0.207)*
     FT3 0.048(0.014~0.081)* 0.045(0.011~0.078)* 0.035(−0.001~0.069)
     FT4 −0.026(−0.038~−0.014)* −0.024(−0.036~−0.012)* −0.010(−0.022~0.003)
     TSH 0.001(−0.274~0.275) −0.005(−0.281~0.270) −0.072(−0.356~0.213)
    噪声
     T3 0.007(−0.001~0.015) 0.003(−0.005~0.010) 0.006(−0.002~0.014)
     T4 −0.139(−0.199~−0.079)* −0.161(−0.221~−0.100)* −0.102(−0.166~−0.038)*
     FT3 0.032(0.014~0.051)* 0.024(0.005~0.043)* 0.017(−0.002~0.037)
     FT4 −0.025(−0.032~−0.019)* −0.024(−0.031~−0.018)* −0.020(−0.027~−0.013)*
     TSH 0.084(−0.065~0.233) 0.079(−0.074~0.231) 0.056(−0.104~0.217)
    [注]*:P<0.05;模型1:不调整协变量;模型2:调整年龄、民族、BMI、教育程度、每月人均收入、婚姻状况、吸烟、饮酒、喝茶、体育锻炼;模型3:调整模型2+职业危害因素。
    下载: 导出CSV
  • [1]

    CITTERIO C E, TARGOVNIK H M, ARVAN P. The role of thyroglobulin in thyroid hormonogenesis[J]. Nat Rev Endocrinol, 2019, 15(6): 323-338. doi: 10.1038/s41574-019-0184-8

    [2]

    LEKO M B, GUNJAČA I, PLEIĆ N, et al. Environmental factors affecting thyroid-stimulating hormone and thyroid hormone levels[J]. Int J Mol Sci, 2021, 22(12): 6521. doi: 10.3390/ijms22126521

    [3]

    KUŚ A, CHAKER L, TEUMER A, et al. The genetic basis of thyroid function: novel findings and new approaches[J]. J Clin Endocrinol Metab, 2020, 105(6): 1707-1721. doi: 10.1210/clinem/dgz225

    [4]

    TAN K, ZHANG Q, WANG Y, et al. Associations between per- and polyfluoroalkyl substances exposure and thyroid hormone levels in the elderly[J]. Sci Total Environ, 2024, 920: 170761. doi: 10.1016/j.scitotenv.2024.170761

    [5]

    INOUE K, RITZ B, ANDERSEN S L, et al. Perfluoroalkyl substances and maternal thyroid hormones in early pregnancy; findings in the Danish national birth cohort[J]. Environ Health Perspect, 2019, 127(11): 117002. doi: 10.1289/EHP5482

    [6]

    BIRCK M G, ALMEIDA-PITITTO B, JANOVSKY C C P S, et al. Thyroid-stimulating hormone and thyroid hormones and incidence of diabetes: prospective results of the Brazilian longitudinal study of adult health (ELSA-BRASIL)[J]. Thyroid, 2022, 32(6): 694-704. doi: 10.1089/thy.2021.0533

    [7]

    ABABZADEH S, RAZAVINIA F S, ESLAMI FARSANI M, et al. Effect of short-term and long-term traffic noise exposure on the thyroid gland in adult rats: a sexual dimorphic study[J]. Horm Mol Biol Clin Investig, 2020, 42(1): 29-35.

    [8]

    VELJOVIĆ V, JOVANOVIĆ J, RADEVIĆ L, et al. Early detection of thyroid disease in workers professionally exposed to noise through preventive medical check-ups[J]. Acta Med Medianae, 2010, 49(3): 45-49.

    [9]

    ZHAO F, ZHANG H, REN D, et al. Association of coal mine dust lung disease with Nodular thyroid disease in coal miners: a retrospective observational study in China[J]. Front Public Health, 2022, 10: 1005721. doi: 10.3389/fpubh.2022.1005721

    [10]

    SONG Q, CHEN X, SU Y, et al. Age and gender specific thyroid hormones and their relationships with body mass index in a large Chinese population[J]. Int J Endocrinol Metab, 2019, 17(1): e66450.

    [11]

    RUGULIES R, SORENSEN K, DI TECCO C, et al. The effect of exposure to long working hours on depression: a systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury[J]. Environ Int, 2021, 155: 106629. doi: 10.1016/j.envint.2021.106629

    [12] 吴玉梅, 刘春兴. 上海地区32745例体检人群甲状腺功能检测结果分析[J]. 海南医学, 2020, 31(3): 299-301. doi: 10.3969/j.issn.1003-6350.2020.03.008

    WU Y M, LIU C X. Analysis of thyroid function in 32745 subjects for health-care examination in Shanghai[J]. Hainan Med J, 2020, 31(3): 299-301. doi: 10.3969/j.issn.1003-6350.2020.03.008

    [13]

    HUANG X, ZHANG X, ZHOU X, et al. Prevalence of thyroid dysfunction in a Chinese population with different glucose intolerance status: a community-based cross-sectional study[J]. Diabetes Metab Syndr Obes, 2020, 13: 4361-4368. doi: 10.2147/DMSO.S271328

    [14]

    WILCOSKY T, WING S. The healthy worker effect. Selection of workers and work forces[J]. Scand J Work Environ Health, 1987, 13(1): 70-72. doi: 10.5271/sjweh.2078

    [15]

    TIAN L, LU C, TENG W. Association between physical activity and thyroid function in American adults: a survey from the NHANES database[J]. BMC Public Health, 2024, 24(1): 1277. doi: 10.1186/s12889-024-18768-4

    [16]

    ZHANG S Y, HU X Q, XIANG C, et al. Physical activity affects dysthyreosis by thyroid hormones sensitivity: a population-based study[J]. Front Endocrinol (Lausanne), 2024, 15: 1418766. doi: 10.3389/fendo.2024.1418766

    [17]

    LEE Y, LEE W, KIM H R. Long working hours and the risk of hypothyroidism in healthy Korean workers: a cohort study[J]. Epidemiol Health, 2022, 44: e2022104. doi: 10.4178/epih.e2022104

    [18]

    LEE Y K, LEE D E, HWANGBO Y, et al. Long work hours are associated with hypothyroidism: a cross-sectional study with population-representative data[J]. Thyroid, 2020, 30(10): 1432-1439. doi: 10.1089/thy.2019.0709

    [19]

    DESCATHA A, SEMBAJWE G, PEGA F, et al. The effect of exposure to long working hours on stroke: a systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury[J]. Environ Int, 2020, 142: 105746. doi: 10.1016/j.envint.2020.105746

    [20]

    KIVIMÄKI M, JOKELA M, NYBERG S T, et al. Long working hours and risk of coronary heart disease and stroke: a systematic review and meta-analysis of published and unpublished data for 603, 838 individuals[J]. Lancet, 2015, 386(10005): 1739-1746. doi: 10.1016/S0140-6736(15)60295-1

    [21]

    MIZOKAMI T, LI A W, EL-KAISSI S, et al. Stress and thyroid autoimmunity[J]. Thyroid, 2004, 14(12): 1047-1055. doi: 10.1089/thy.2004.14.1047

    [22]

    FISCHER F M, SILVA-COSTA A, GRIEP R H, et al. Working Time Society consensus statements: psychosocial stressors relevant to the health and wellbeing of night and shift workers[J]. Ind Health, 2019, 57(2): 175-183. doi: 10.2486/indhealth.SW-3

    [23]

    LESO V, VETRANI I, SICIGNANO A, et al. The impact of shift-work and night shift-work on thyroid: a systematic review[J]. Int J Environ Res Public Health, 2020, 17(5): 1527. doi: 10.3390/ijerph17051527

    [24]

    KHOSRAVIPOUR M, GHARAGOZLOU F, KAKAVANDI M G, et al. Association of prolonged occupational co-exposures to electromagnetic fields, noise, and rotating shift work with thyroid hormone levels[J]. Ecotoxicol Environ Saf, 2024, 270: 115837. doi: 10.1016/j.ecoenv.2023.115837

    [25]

    KALSBEEK A, FLIERS E. Daily regulation of hormone profiles[M]//KRAMER A, MERROW M. Circadian Clocks. Berlin, Heidelberg: Springer, 2013: 185-226.

    [26]

    ORTIGA-CARVALHO T M, CHIAMOLERA M I, PAZOS-MOURA C C, et al. Hypothalamus-pituitary-thyroid axis[J]. Compr Physiol, 2016, 6(3): 1387-1428.

    [27]

    IKEGAMI K, REFETOFF S, VAN CAUTER E, et al. Interconnection between circadian clocks and thyroid function[J]. Nat Rev Endocrinol, 2019, 15(10): 590-600. doi: 10.1038/s41574-019-0237-z

    [28]

    WANG C, ZENG F, XU C, et al. Anomalous enrichment of as and hg in underground coal dust: a case from Xishan coalfield, Shanxi Province, North China[J]. ACS Omega, 2023, 8(15): 13884-13898. doi: 10.1021/acsomega.3c00300

    [29]

    KIM K, ARGOS M, PERSKY V W, et al. Associations of exposure to metal and metal mixtures with thyroid hormones: results from the NHANES 2007-2012[J]. Environ Res, 2022, 212(Pt C): 113413.

    [30]

    PALAZZOLO D L, JANSEN K P. The minimal arsenic concentration required to inhibit the activity of thyroid peroxidase activity in vitro[J]. Biol Trace Elem Res, 2008, 126(1/3): 49-55.

    [31]

    CHEN A, KIM S S, CHUNG E, et al. Thyroid hormones in relation to lead, mercury, and cadmium exposure in the National Health and Nutrition Examination Survey, 2007-2008[J]. Environ Health Perspect, 2013, 121(2): 181-186. doi: 10.1289/ehp.1205239

    [32]

    GHOSH N, BHATTACHARYA S. Thyrotoxicity of the chlorides of cadmium and mercury in rabbit[J]. Biomed Environ Sci, 1992, 5(3): 236-240.

    [33]

    SOLDIN O P, O'MARA D M, ASCHNER M. Thyroid hormones and methylmercury toxicity[J]. Biol Trace Elem Res, 2008, 126(1/3): 1-12.

    [34]

    KHOSRAVIPOUR M, KAKAVANDI M G, NADRI F, et al. The long-term effects of exposure to noise on the levels of thyroid hormones: a four-year repeated measures study[J]. Sci Total Environ, 2021, 792: 148315. doi: 10.1016/j.scitotenv.2021.148315

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  • 收稿日期:  2024-07-02
  • 录用日期:  2025-02-17
  • 刊出日期:  2025-04-24

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