军事航海作业慢性疲劳综合征动物模型的研究进展

Progress in animal model studies on chronic fatigue syndrome in military seafaring operations

  • 摘要: 慢性疲劳综合征(CFS)是军事航海作业常见问题,极大影响军事作业安全。采用动物模型开展CFS发生机制、治疗措施等研究,是解决这一问题的常用方法。本文系统介绍了单因素、多因素CFS模型构建方法,归纳了CFS常见的评价指标,包括行为学指标和生化指标,结合目前军事作业CFS的普遍诱因,如长时间连续工作、高强度体力活动、睡眠剥夺、心理压力及极端环境条件,总结出军事航海作业CFS动物模型的主要特点。这些特点包括但不限于慢性疲劳、睡眠障碍、认知功能受损、心理应激反应和生化指标异常。此外,本文展望未来军事航海作业CFS动物模型所应开展的主要工作,进一步提高军事航海作业CFS动物模型的应用价值,为军事人员健康保障和疾病防治提供有力支持。

     

    Abstract: Chronic fatigue syndrome (CFS) is a common problem in military maritime navigation, which greatly affects the safety of military missions. The use of animal models to carry out research on the mechanism of CFS and treatment measures is a common method. This paper systematically introduced the construction methods of CFS models such as single-factor and multi-factor models, summarized common evaluation indicators of CFS, including behavioral and biochemical indicators, and summed up key characteristics of CFS animal models in military oceanic navigation combined with common causes of CFS in military contexts, such as prolonged continuous work, high-intensity physical activity, sleep deprivation, psychological stress, and extreme environmental conditions. The key characteristics of the animal models included, but not limited to, chronic fatigue, sleep disorders, impaired cognitive function, psychological stress responses, and abnormal biochemical indicators. Furthermore, this article identified future research directions for CFS animal models in military oceanic navigation to enhance the application value of the models and provide robust support for the health protection and disease prevention of military personnel.

     

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