杂亚格日里, 李敬光, 王雨昕, 崔师伟, 张磊, 孙新. 电子垃圾回收地区与一般暴露地区新生儿脐血全氟与多氟烷基化合物暴露水平比较[J]. 环境与职业医学, 2024, 41(8): 876-883. DOI: 10.11836/JEOM24013
引用本文: 杂亚格日里, 李敬光, 王雨昕, 崔师伟, 张磊, 孙新. 电子垃圾回收地区与一般暴露地区新生儿脐血全氟与多氟烷基化合物暴露水平比较[J]. 环境与职业医学, 2024, 41(8): 876-883. DOI: 10.11836/JEOM24013
Zaya GERILI, LI Jingguang, WANG Yuxin, CUI Shiwei, ZHANG Lei, SUN Xin. Comparison of per- and polyfluoroalkyl substance exposure levels in neonatal cord blood between an e-waste recycling area and a general exposure area[J]. Journal of Environmental and Occupational Medicine, 2024, 41(8): 876-883. DOI: 10.11836/JEOM24013
Citation: Zaya GERILI, LI Jingguang, WANG Yuxin, CUI Shiwei, ZHANG Lei, SUN Xin. Comparison of per- and polyfluoroalkyl substance exposure levels in neonatal cord blood between an e-waste recycling area and a general exposure area[J]. Journal of Environmental and Occupational Medicine, 2024, 41(8): 876-883. DOI: 10.11836/JEOM24013

电子垃圾回收地区与一般暴露地区新生儿脐血全氟与多氟烷基化合物暴露水平比较

Comparison of per- and polyfluoroalkyl substance exposure levels in neonatal cord blood between an e-waste recycling area and a general exposure area

  • 摘要:
    背景  全氟与多氟烷基化合物(PFAS)是一类典型的持久性有机污染物。PFAS工业生产与消费是城市地区该物质暴露主要原因。而电子垃圾回收活动也是PFAS环境暴露的重要来源之一。
    目的 比较电子垃圾回收地区与以现代化经济发展为背景的一般暴露地区(后称一般暴露地区)新生儿脐带血清中传统及新型PFAS暴露表征差异。
    方法 依托于2018年开展的一项出生队列,以募集的85例孕妇为研究对象(电子垃圾回收地区孕妇36名,一般暴露地区孕妇49名)。孕妇分娩时采集新生儿脐带血,应用超高效液相色谱-串联质谱方法检测血液常见的28种PFAS暴露水平,采用结构式问卷调查孕妇的社会人口学特征。采用Mann-Whitney U检验比较电子垃圾回收地区与一般暴露地区新生儿PFAS暴露水平。以地区因素为自变量,以自然对数转化的PFAS暴露水平为应变量,采用多因素线性回归模型探究是否为电子垃圾回收地区对新生儿PFAS暴露特征的影响。
    结果 新生儿脐带血中共检出22种PFAS,其中13种同系物在两个地区样本检出率均为100%。电子垃圾回收地区和一般暴露地区新生儿脐带血∑PFAS暴露水平中位数分别为14.19和14.02 ng·mL−1,其中直链全氟辛酸(L-PFOA)暴露水平最高,中位数浓度分别为5.49和6.39 ng·mL−1。经Mann-Whitney U检验发现,电子垃圾回收地区脐带血中长链全氟癸酸(PFDA)、全氟十一酸(PFUnDA)、全氟十二酸(PFDoDA)和全氟十三酸(PFTrDA)以及全氟辛烷磺酸新型替代物6∶2氯代多氟烷基醚磺酸盐(6∶2 Cl-PFESA)和8∶2氯代多氟烷基醚磺酸盐(8∶2 CI-PFESA)暴露水平中位数高于一般暴露地区;而短链全氟戊酸(PFPeA)、全氟己酸(PFHxA)以及全氟辛酸(PFOA)的支链异构体包括全氟-6-甲基庚酸(iso-PFOA)、全氟-5-甲基庚酸(5m-PFOA)和全氟-4-甲基庚酸(4m-PFOA)暴露水平中位数低于一般暴露地区(P<0.05)。多因素线性回归调整模型发现,与一般暴露地区相比,电子垃圾回收地区脐带血中长链PFDA、PFUnDA、PFDoDA、PFTrDA,与新型替代物6:2 Cl-PFESA和8:2 Cl-PFESA暴露水平升高至1.95(95%CI:1.39~2.75)、2.10(95%CI:1.58~2.75)、2.12(95%CI:1.39~3.25)、2.64(95%CI:1.63~4.22)、3.46(95%CI:2.34~5.10)和3.25(95%CI:2.01~5.26)倍;而短链PFPeA、PFHxA、支链PFOA(br-PFOA)暴露水平是其0.44(95%Cl:0.38~0.52)、0.30(95%Cl:0.16~0.57)、0.50(95%Cl:0.38~0.67)倍。
    结论 电子垃圾回收地区和一般暴露地区新生儿脐带血清中PFAS广泛存在。与一般暴露地区比较,电子垃圾回收地区新生儿脐带血中部分长链全氟烷酸(PFCA)与新兴PFAS替代物暴露水平更高,而一般暴露地区部分短链PFCA与PFOA支链异构体暴露水平更高。

     

    Abstract:
    Background Per- and polyfluoroalkyl substances (PFAS) are a class of persistent organic pollu-tants. Industrial production and consumer use of PFAS are the primary sources of exposure in urban areas. E-waste recycling activities are also a significant source of environmental PFAS exposure.
    Objective To compare exposure profiles between traditional and emerging PFAS in neonatal cord blood collected from an e-waste recycling area and a general exposure area characterized by modern economic development (hereafter referred to as general exposure area).
    Methods Based on a birth cohort study conducted in 2018, 85 pregnant women were recruited (36 participants from an e-waste recycling area and 49 participants from a general exposure area). Neonatal cord blood was collected at delivery. Ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was used to detect 28 common PFAS in the blood. A structured questionnaire was used to gather sociodemographic characteristics of the pregnant women. Mann-Whitney U tests were used to compare PFAS exposure levels in neonatal cord blood between the e-waste recycling area and the general exposure area. Multiple linear regression models were used to explore the influence of residing in the e-waste recycling area on neonatal PFAS exposure, with area as the independent variable and the natural logarithm of PFAS exposure levels as the dependent variable.
    Results A total of 22 PFAS were positive in neonatal cord blood, of which 13 congeners were 100% detectable in the samples from both areas. The median ∑PFAS exposure levels in neonatal cord blood were 14.19 ng·mL−1 and 14.02 ng·mL−1 for the e-waste recycling area and the general exposure area, respectively, with linear perfluorooctanoic acid (L-PFOA) showing the highest median concentration (5.49 ng·mL−1 and 6.39 ng·mL−1, respectively). The results of Mann-Whitney U tests showed that the median exposure levels of long-chain perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUnDA), perfluorododecanoic acid (PFDoDA), and perfluorotridecanoic acid (PFTrDA), as well as emerging alternatives 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) and 8:2 chlorinated polyfluorinated ether sulfonate (8:2 Cl-PFESA), were higher in the e-waste recycling area than in the general exposure area. In contrast, the median exposure levels of short-chain perfluoropentanoic acid (PFPeA) and perfluorohexanoic acid (PFHxA), as well as perfluorooctanoic acid (PFOA) branched isomers, including perfluoro-6-methylheptanoic acid (iso-PFOA), perfluoro-5-methylheptanoic acid (5m-PFOA), and perfluoro-4-methylheptanoic acid (4m-PFOA), were lower in the e-waste recycling area than in the general exposure area (P<0.05). The multiple linear regression models showed that, compared to the general exposure area, neonatal cord blood in the e-waste recycling area had significantly higher exposure levels of long-chain PFDA, PFUnDA, PFDoDA, PFTrDA, and emerging alternatives 6:2 Cl-PFESA and 8:2 Cl-PFESA, with odds ratios of 1.95 (95%CI: 1.39-2.75), 2.10 (95%CI: 1.58-2.75), 2.12 (95%CI: 1.39-3.25), 2.64 (95%CI: 1.63-4.22), 3.46 (95%CI: 2.34-5.10), and 3.25 (95%CI: 2.01-5.26), respectively. Conversely, the exposure levels of short-chain PFPeA, PFHxA, and branched PFOA (br-PFOA) were significantly lower, with odds ratios of 0.44 (95%CI: 0.38-0.52), 0.30 (95%CI: 0.16-0.57), and 0.50 (95%CI: 0.38-0.67), respectively.
    Conclusion PFAS are widely present in neonatal cord blood in both the e-waste recycling area and the general exposure area. Compared to the general exposure area, the neonatal cord blood samples in the e-waste recycling area show higher exposure levels of certain long-chain perfluoroalkyl carboxylic acids (PFCA) and emerging PFAS alternatives, while the neonatal cord blood samples in the general exposure area show higher exposure levels of some short-chain PFCA and PFOA branched isomers.

     

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