关注膳食营养与帕金森病前驱期,主动应对老龄化挑战

Concern for nutrition and prodromal Parkinson's disease and actively respond to aging challenge

  • 摘要: 帕金森病(PD)是常见于中老年人群中的慢性神经退行性疾病,老龄化是PD的最大风险因素。随着我国老龄化进程的加快,持续加重的PD患病形势严重影响了老年人的身心健康和生命质量。“神经系统疾病专病社区队列研究”(CCSNSD)分别建立了癫痫、阿尔茨海默病和PD社区人群队列,并完成基线调查和1轮随访调查,广泛收集了人口经济特征、社区环境因素、膳食及生活方式、认知功能、慢性病病史、PD相关危险因素等数据,为开展膳食营养与PD相关结局的关系研究提供了可能。本专栏利用CCSNSD两轮调查数据,分析了我国四省55岁及以上人群的帕金森病前驱期(pPD)风险水平及其人口经济差异;分别探讨了红肉及加工肉制品摄入、乳制品摄入及认知功能与pPD风险的关联;还综述了关于膳食营养、生活方式和PD风险的既往研究结果。但CCSNSD随访时间较短,对于PD的发病风险及其影响因素分析,有待后续对该队列较长时期的追踪并结合临床检查与诊断结果展开进一步的研究。

     

    Abstract: Parkinson's disease (PD) is a chronic neurodegenerative disease commonly seen in middle-aged and elderly people, and aging is the largest risk factor for PD. With acceleration of the aging process in China, the wellbeing and life quality of the elderly are expected to be disturbed by increasing prevalence of PD. The Community-based Cohort Study on Nervous System Diseases (CCSNSD) has established community population-based cohorts of epilepsy, Alzheimer's disease, and PD, respectively; baseline survey and one round of follow-up have finished so far. The CCSNSD collected data on demographics, community environment, diet, lifestyle, cognition, history of chronic diseases, and PD-related risk factors and facilitated exploration of the relationship between dietary nutrition and PD-related outcomes. This special column described status on prodromal Parkinson's disease (pPD) risk and its demographic & economic differences among people aged 55 and above in four provinces of China, and investigated the associations of red meat and processed meat products intake , dairy products intake, and cognitive function with pPD risk, respectively. Furthermore, one paper reviewed previous studies on dietary nutrition, lifestyle, and PD risks. However, the follow-up time of CCSNSD was relatively short as of the publishing of this column, longer follow-ups are required to allow studying potential factors and risk of incident PD combined with clinical examination and diagnosis of PD.

     

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