室内空气污染与人群尿8-羟基脱氧鸟苷相关性研究进展
Advances on association between indoor air pollution and 8-hydroxydeoxyguanosine in human urine
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摘要:
尿8-羟基脱氧鸟苷（8-OHdG）是反映机体氧化应激及DNA氧化损伤的标志物。人一生有80%~90%的时间在室内度过，室内空气质量直接关系到人体健康。本文介绍了不同人口特征、生活方式、职业暴露、健康状态的人群尿8-OHdG水平，阐述了影响人群尿8-OHdG浓度的室内空气污染因素，包括室外来源的污染物、吸烟、室内燃烧及烹调油烟、室内装修材料中的化学物质、建筑物地基。通过测定人群尿8-OHdG浓度，为推测室内空气污染对人群健康的影响（DNA氧化损伤和相关疾病）提供理论依据。
Abstract: 8-hydroxydeoxyguanosine (8-OHdG) in human urine is a marker reflecting oxidative stress and DNA oxidative damage. People spend 80%-90% of their life indoors; therefore, indoor air quality is directly related to human health. In this paper, the urinary 8-OHdG levels were presented in populations grouped by different demographic characteristics, lifestyle, occupational exposure, and health status, and elucidated indoor pollutants affecting human urinary 8-OHdG level, such as pollutants from outdoor sources, smoking, indoor combustion and cooking fumes, the chemicals in interior decoration materials, and building foundation soils. The article aims to provide a theoretical basis for predicting the impact of indoor air pollution on human health (DNA oxidative damage and related diseases) by measuring the concentration of 8-OHdG in human urine.
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