肠道益生菌缓解慢性重金属毒性的研究进展
Research progress on intestinal probiotics alleviating chronic heavy metal toxicity
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摘要:
人类活动及工业生产扩大了重金属对环境的污染，尤其是污染食物链后引起人群不同程度的中毒。研究表明重金属暴露易打破菌群平衡，进一步加重器官毒性，而以乳酸杆菌为代表的肠道益生菌可主动吸附重金属离子，促进其排出体外，并减少其诱导的氧化应激损伤、炎症反应。本文针对长期低剂量重金属暴露易产生的慢性毒性，综述了几类常见重金属（铅、镉、汞）污染现状，分析了重金属与肠道菌群及益生菌间的相互作用关系，同时总结了益生菌缓解慢性重金属毒性不同的作用机制。这将为有效防治重金属诱导的器官毒性提供新的思路。
Abstract: Human activities, especially industrial production, have aggravated the pollution of heavy metals in the environment, and especially after disrupting the food chain, such pollution can cause varying degrees of heavy metal poisoning in human beings. Studies have shown that exposure to heavy metals tends to upset the balance of the flora and further aggravate organ toxicity. Intestinal probiotics represented by Lactobacillus can actively adsorb heavy metal ions, promote their excretion, and reduce their induced oxidative stress injury and inflammatory response. Focusing on the chronic toxicity induced by long-term low-dose exposure to heavy metals, this article reviewed current pollution status of several common heavy metals (lead, cadmium, and mercury), analyzed the interaction between heavy metals, intestinal flora, and probiotics, and summarized proposed mechanisms of probiotics in mitigating chronic heavy metal toxicity, aiming to provide new ideas for effective prevention and treatment of organ toxicity induced by heavy metals.
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