聚六亚甲基胍毒性研究进展
Advances on toxicity of polyhexamethyl guanidine
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摘要:
聚六亚甲基胍（PHMG）是一种被广泛使用的胍类消毒剂。自韩国发生加湿器消毒剂（主要成分是PHMG）肺损伤事件以来，其吸入毒性引起了研究者的重视与关注。目前国内关于吸入PHMG毒性的研究较少，本文在国内外研究基础上对PHMG的吸入毒性及其他毒性做一综述，系统性介绍了目前已经报道的PHMG毒性，包括吸入毒性及其毒性机制和其他可能毒性如肝脏毒性、心血管毒性、免疫毒性以及生殖和发育毒性，揭示了不规范使用PHMG对机体的影响及其可能的机制，为我国合理使用PHMG消毒剂和后续开展相关研究奠定理论基础与提供科学依据。
Abstract: Polyhexamethyl guanidine (PHMG) is a widely used guanidine disinfectant. Since a lung injury incident induced by humidifier disinfectant (PHMG was identified as a main component) was reported in Korea, its inhalation toxicity has attracted the attention of researchers. At present, there are few domestic studies on inhalation toxicity of PHMG. In this paper, based on the domestic and foreign studies of PHMG, the toxicities of PHMG, including inhalation toxicity and associated toxic mechanism, and other potential toxicities, such as liver toxicities, cardiovascular toxicity, immunotoxicity, and reproductive and developmental toxicity, were systematically introduced, revealing that the effects of use of PHMG in a non-standard manner on the body and its possible mechanisms, which could provide reference for the use of PHMG properly and to lay a theoretical foundation and provide a scientific basis for follow-up study.
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