丙烯腈作业工人尿硫氰酸盐水平及健康效应
Urinary Thiocyanate Levels and Health Effects in Workers Exposed to Acrylonitrile
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摘要:
目的 调查接触低水平丙烯腈作业工人的尿硫氰酸盐浓度及健康效应,探讨其是否可作为低水平丙烯腈暴露的接触指标。 方法 选取某化工企业接触丙烯腈工人315名作为研究对象,进行常规职业健康检查,并采用吡啶-巴比妥酸比色法测定尿硫氰酸盐浓度。 结果 丙烯腈作业工人尿硫氰酸盐浓度呈正偏态分布,中位数为4.95 mg/L,四分位间距为4.84 mg/L。尿硫氰酸盐浓度与吸烟、饮酒及其他健康效应均未显示出统计学关联。 结论 尿硫氰酸盐含量不能作为低水平丙烯腈暴露的接触指标。 Abstract:Objective To determine the levels and health effects of urinary thiocyanate (USCN) in workers exposed to low-level acrylonitrile, and to discuss if USCN levels can be used as an indicator of low-level acrylonitrile exposure. Methods A total of 315 workers from a chemical factory located in Panjin city were recruited as study subjects and received occupational health examination. The USCN levels were determined by pyrideine-barbituric acid spectrophotometry. Results The distribution of USCN levels was positively skewed, its median was 4.95 mg/L and the inter-quartile range was 4.84 mg/L. No significant associations of USCN levels were observed with alcohol consumption, cigarette smoking, and other health parameters. Conclusion Thiocyanate level in random urine samples is not capable of serving as a biomarker of low-level acrylonitrile exposure.
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