二甲基乙酰胺职业接触及与尿中甲基乙酰胺的关系
Correlation between Urinary N-methylacetamide and Occupational Exposure to N, N-dimethylacetamide
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摘要:
目的 探讨职业二甲基乙酰胺(DMAC)接触与尿中甲基乙酰胺(NMAC)的相关性。 方法 对3 家氨纶生产企业6 个工种201 名工人进行空气中DMAC暴露浓度监测及工作周末班末尿样采集,同时对20 名纺丝工连续一周空气样品和班末尿样的采集;分别用气相色谱测定空气中DMAC和尿中NMAC含量。 结果 氨纶生产过程中组件清洗工、纺丝工接触DMAC水平最高(P<0.003 3),中位数分别为32.10、22.02 mg/m3,其尿中NMAC浓度较其他工种高(P<0.003 3),中位数分别为30.09、22.72 mg/gCr;工作周末班末尿NMAC 含量与空气中DMAC 浓度呈直线相关,直线方程为log(U-NMAC)=0.685+0.455& #215;log(A-DMAC)(r=0.698,P= 0.001);长期DMAC接触者,接触2 d 后尿中NMAC呈较高水平(P<0.003 3);个体DMAC 接触代谢转化为NMAC 的相对内暴露指数(RIE)与DMAC 接触浓度呈负相关(rs=-0.781,P=0.001)。 结论 工作周末班末尿NMAC含量与空气中DMAC浓度呈良好对数线性关系。 Abstract:Objective To examine the correlation between occupational N, N-dimethylacetamide (DMAC) exposures and urinary N-methylacetamide (NMAC). Methods A total of 201 workers of 6 work types exposed to DMAC in 3 spandex factories were recruited. Air samples were collected from each work type site, post-shift urine samples at the end of workweek were collected from all studied workers and also from 20 spinning workers at each end of workday for 5 consecutive days. NMAC in urine and DMAC in air were determined by gas chromatography. Results The time-weighted average (TWA) air levels of DMAC were highest in module washing and spinning sites (P<0.003 3), medians being 32.10 and 22.02 mg/m3 respectively. The urinary NMAC concentrations in module washing workers and spinning workers were significantly higher than workers of other work types, medians being 30.09 and 22.72 mg/gCr respectively. A linear correlation was found between the TWA air levels of DMAC and the creatinineadjusted NMAC levels in urine collected by the end of workweek (r=0.698, P= 0.001). The linear equation was log(U-NMAC)= 0.685+0.455& #215;log(A-DMAC). After 2 consecutive days of exposure, the urinary NMAC was at a higher level in chronically exposed workers (P<0.003 3). A negative linear correlation was found between the DMAC levels in air and the relative internal exposure (RIE) (rs=-0.781, P= 0.001). Conclusion Air DMAC contents are significantly correlated with urinary NMAC concentrations after logarithmic transformation.
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