邱月锋, 林勇, 黄萌, 陈星, 何斐, 樊丽辉, 陈俊磊, 蔡琳. 吸烟、居住环境、基因多态性与肺癌发病风险的关系[J]. 环境与职业医学, 2011, 28(3): 133-136,140.
引用本文: 邱月锋, 林勇, 黄萌, 陈星, 何斐, 樊丽辉, 陈俊磊, 蔡琳. 吸烟、居住环境、基因多态性与肺癌发病风险的关系[J]. 环境与职业医学, 2011, 28(3): 133-136,140.
QIU Yue-feng , LIN Yong , HUANG Meng , CHEN Xing , HE Fei , FAN Li-hui , CHEN Jun-lei , CAI Lin . Association of Smoking, Residential Environment and Polymorphisms with Lung Cancer[J]. Journal of Environmental and Occupational Medicine, 2011, 28(3): 133-136,140.
Citation: QIU Yue-feng , LIN Yong , HUANG Meng , CHEN Xing , HE Fei , FAN Li-hui , CHEN Jun-lei , CAI Lin . Association of Smoking, Residential Environment and Polymorphisms with Lung Cancer[J]. Journal of Environmental and Occupational Medicine, 2011, 28(3): 133-136,140.

吸烟、居住环境、基因多态性与肺癌发病风险的关系

Association of Smoking, Residential Environment and Polymorphisms with Lung Cancer

  • 摘要: 目的 探讨肺癌发病的危险因素。

    方法 采用病例对照研究方法,收集病例和对照各781例,进行流行病学调查及实验检测分析。

    结论 室内烹调油烟、装修后刺激性气味、居室通风不良、吸烟、常自己炒菜可增加肺癌风险;而烧菜油温不过热和BRCA2基因rs144848 C等位基因具有保护作用。吸烟、室内烹调油烟和居住平房具有交互作用。

    结论 肺癌与吸烟、环境污染有关,rs144848位点C等位基因可能具有保护作用。

     

    Abstract: Objective To reveal risk factors of lung cancer.

    Methods A case-control study was designed with 781 lung cancer patients and 781 control subjects. Both epidemiological investigation and laboratory examination were performed in every subject.

    Results We revealed that smoke during cooking, irritant smell after decoration, insufficient ventilation, smoking and cooking presented increased risk of developing lung cancer. The low temperature of oil during cooking and rs144848 C allele were identified as protective factors. Smoking, smoke during cooking and living in bungalow showed a synergic effect.

    Conclusion The results suggest that smoking and air pollution are associated with lung caner. Rs144848 C allele may have protective effect on lung cancer.

     

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