王克跃, 金泰廙. 低浓度镉暴露对工人肾功能及体液中铁和锌水平的影响[J]. 环境与职业医学, 2011, 28(12): 738-740,743.
引用本文: 王克跃, 金泰廙. 低浓度镉暴露对工人肾功能及体液中铁和锌水平的影响[J]. 环境与职业医学, 2011, 28(12): 738-740,743.
WANG Ke-yue , JIN Tai-yi . Effects of Low Level Cadmium Exposure on Renal Function and Alteration of Iron and Zinc Levels in Body Fluid among Workers[J]. Journal of Environmental and Occupational Medicine, 2011, 28(12): 738-740,743.
Citation: WANG Ke-yue , JIN Tai-yi . Effects of Low Level Cadmium Exposure on Renal Function and Alteration of Iron and Zinc Levels in Body Fluid among Workers[J]. Journal of Environmental and Occupational Medicine, 2011, 28(12): 738-740,743.

低浓度镉暴露对工人肾功能及体液中铁和锌水平的影响

Effects of Low Level Cadmium Exposure on Renal Function and Alteration of Iron and Zinc Levels in Body Fluid among Workers

  • 摘要: 目的 探讨通过呼吸道职业性接触镉的情况下,工人体液中铁和锌的水平与镉肾毒作用间的相互关系。

    方法 随机抽取镉接触工人103人和对照组人员36人,分别测定镉接触标志物血镉(blood cadmium,BCd)和尿镉(urinary cadmium,UCd)、镉肾毒性的效应标志物尿β2-微球蛋白(urinary β2-microglobulin,Uβ2-MG)、尿白蛋白(urinary albumin,UALB)和尿N-乙酰-β-D-氨基葡萄糖苷酶(urinary N-acetyl-β-D-glucosaminidase,UNAG)和反映铁状态的生物标志物血红蛋白(Hb)、血清铁蛋白(serum ferritin,SF)和血清转铁蛋白受体(serum transferrin receptor,sTfR),测定血锌和尿锌来反映体液中锌水平,并分析这些标志物间的相互关系。

    结果 镉接触工人的血镉、尿镉均明显增高,尿β2-MG和UALB均高于对照组,尿NAG、β2-MG和UALB均随尿镉水平的增高而增高,存在剂量-效应关系,Hb含量和SF低于对照组,贫血患病率高于对照组。接触组血锌和尿锌含量与对照组的差异无统计学意义,但是尿锌与尿镉和血镉间均呈正相关关系,尿镉高的工人尿锌浓度高于尿镉低的工人。

    结论 职业性镉接触能引起体内铁储存量下降和贫血患病率增高,在体内镉蓄积到一定程度时,会引起尿锌排泄增加。

     

    Abstract: Objective To explore the interaction between iron & zinc levels in body fluid and cadmium (Cd) induced nephrotoxicity through occupational respiratory exposure.

    Methods The biomarkers of Cd exposureblood cadmium (BCd) and urinary cadmium (UCd), Cd nephrotoxicityurinary β2-microglobulin (Uβ2-MG), urinary albumin (UALB) and urinary N-acetyl-β-D-glucosaminidase (UNAG), and iron & zinc levelsblood zinc (BZn), urinary zinc (UZn), hemoglobin (Hb), serum ferritin (SF) and serum transferrin receptor (sTfR) in the body fluid of 103 Cd-exposed workers and 36 controls randomly selected were measured respectively and the relationships between them were analyzed.

    Results Compared with the control group, the contents of BCd, UCd, Uβ2-MG and UALB elevated in the cadmium exposed workers. UNAG, Uβ2-MG and UALB showed positive association with UCd in a dose-dependent manner. Hb and SF decreased in the exposed group, and the prevalence of anemia increased. Although there was no statistical difference in BZn and UZn between the exposed and control groups, a positive correlation between UZn and UCd existed.

    Conclusion The results suggest that occupational exposure to Cd can result in a decrease of iron storage in body and an increase of anemia prevalence. Excretion of UZn will increase if Cd accumulates to a certain degree in body.

     

/

返回文章
返回