上海市某区甲型H1N1流行性感冒疫苗接种安全性监测
Safety Monitoring of Influenza A (H1N1) Vaccination in a District of Shanghai
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摘要:
目的 监测2009-2010年上海市长宁区甲型H1N1流行性感冒(甲流)疫苗接种的安全性。 方法 通过上海市预防接种异常反应(adverse events following immunization,AEFI)监测系统,以被动监测方式收集长宁区甲流疫苗接种人群截至2010年12月31日的AEFI个案信息,同时通过问卷和电话随访的主动监测方式收集其中4所中小学校师生的AEFI个案信息开展评价。 结果 上海市长宁区共接种甲流疫苗86 934人,甲流疫苗AEFI被动监测报告发生率为53.04/10万,其中异常反应报告发生率为8.25/10万;4所中小学校接种甲流疫苗2 092人,甲流疫苗AEFI主动监测报告发生率为8 221.80/10万,主动监测的AEFI报告发生率明显高于被动监测。甲流疫苗AEFI报告对象的临床表现以发热、局部反应和主诉不适为主,异常反应以过敏性反应为主,无严重不良反应发生。 结论 甲流疫苗AEFI被动监测的漏报情况主要发生在一般反应,甲流疫苗的安全性与季节性流行性感冒疫苗相当。 Abstract:Objective To monitor the safety of an influenza A (H1N1) vaccination during 2009-2010 in Changning District of Shanghai. Methods The data on adverse events following immunization (AEFI) were collected following a mass influenza A (H1N1) vaccination through a passive surveillance system and an active surveillance using questionnaire and telephone interview among students and teachers of 4 elementary and middle schools. Results A total of 86 934 influenza A (H1N1) vaccine shots were administered during the study period in this district. The reported AEFI incidence through the passive surveillance system was 53.04 per 100 000, with the adverse events incidence of 8.25 per 100 000. A group of 2 092 influenza A (H1N1) vaccine shots were administered in the 4 elementary and middle schools. The reported AEFI incidence through the active surveillance system was 8 221.80 per 100 000, which was higher than that through the passive surveillance significantly. The syndromes reported by AEFI were mainly fever, local reaction and discomfort. The leading moderate adverse event was allergy. No severe adverse event was reported. Conclusion The events failed to report are mainly mild symptoms. The reported influenza A (H1N1) vaccine is considered safe in a large scale of inoculation.
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