段蕾, 聂继盛. B[a]P所致神经发育毒性的研究进展[J]. 环境与职业医学, 2011, 28(11): 697-700.
引用本文: 段蕾, 聂继盛. B[a]P所致神经发育毒性的研究进展[J]. 环境与职业医学, 2011, 28(11): 697-700.
DUAN Lei , NIE Ji-sheng . Advancement in Research of Benzo[a]pyrene Toxicity on Neurodevelopment[J]. Journal of Environmental and Occupational Medicine, 2011, 28(11): 697-700.
Citation: DUAN Lei , NIE Ji-sheng . Advancement in Research of Benzo[a]pyrene Toxicity on Neurodevelopment[J]. Journal of Environmental and Occupational Medicine, 2011, 28(11): 697-700.

BaP所致神经发育毒性的研究进展

Advancement in Research of Benzoapyrene Toxicity on Neurodevelopment

  • 摘要: BaP (benzoapyrene,BaP)是重要的职业和环境污染物之一,它的神经发育毒性与致癌性\致畸性相比虽是一种弱效应,但会对处于发育中的机体造成不良后果,尤其是中枢神经系统对其更为敏感。本课题组以近年来国内外有关BaP神经发育毒性的研究为基础,综述其流行病学研究、实验动物研究以及可能的毒性机制等方面研究进展;结合本课题组的已有研究,认为由于BaP的神经发育毒性所致学习和记忆损伤应得到广泛关注。

     

    Abstract: Benzoapyrene (BaP) is one of the most important occupational and environmental contaminants. Compared with its carcinogenicity and teratogenicity, its toxicity on neurodevelopment is a weak effect, but could cause serious and adverse consequences for the developing individuals, especially for the central nervous system, which is a very sensitive target. In this paper, based on the research progresses of BaP toxicity on neurodevelopment at home and abroad, we summarized the epidemiological studies, neurotoxicity in animal models, and plausible mechanism due to BaP exposure. Combined with our previous study, more attention should be paid to the damage to learning and memory by BaP exposure.

     

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