邵一鸣, 潘杰, 洪新宇, 周志俊. 重金属对睡眠影响的研究进展[J]. 环境与职业医学, 2021, 38(12): 1383-1386. DOI: 10.13213/j.cnki.jeom.2021.21122
引用本文: 邵一鸣, 潘杰, 洪新宇, 周志俊. 重金属对睡眠影响的研究进展[J]. 环境与职业医学, 2021, 38(12): 1383-1386. DOI: 10.13213/j.cnki.jeom.2021.21122
SHAO Yiming, PAN Jie, HONG Xinyu, ZHOU Zhijun. Review on effects of heavy metals on sleep[J]. Journal of Environmental and Occupational Medicine, 2021, 38(12): 1383-1386. DOI: 10.13213/j.cnki.jeom.2021.21122
Citation: SHAO Yiming, PAN Jie, HONG Xinyu, ZHOU Zhijun. Review on effects of heavy metals on sleep[J]. Journal of Environmental and Occupational Medicine, 2021, 38(12): 1383-1386. DOI: 10.13213/j.cnki.jeom.2021.21122

重金属对睡眠影响的研究进展

Review on effects of heavy metals on sleep

  • 摘要:

      铅、镉、锰、汞等重金属是工业生产的重要原料及辅料,环境中重金属污染不断加重。早期的重金属毒理学数据多来源于职业病患者的临床资料,如今普通成年人群和婴幼儿及青少年人群也逐渐成为重金属健康危害的研究对象。流行病学资料和实验室研究均明确表明重金属具有神经系统毒性,而睡眠则是由中枢神经系统协调控制。本文基于流行病学研究,综述了重金属对职业人群和非职业人群(包括普通成年人群和婴幼儿及青少年人群)睡眠的影响;同时,从睡眠-觉醒周期和与睡眠相关的神经化学物质两方面,介绍了重金属对睡眠影响的机制。

     

    Abstract:

      Heavy metals including lead, cadmium, manganese, and mercury are important raw materials and auxiliary materials in industrial production, but they are also seriously polluting the environment. While most of the early toxicological data on heavy metals are derived from studying occupational exposure populations, the general adult population and the infants and adolescents are now increasingly being studied for the health hazards of heavy metals. Epidemiological and laboratory studies have clearly demonstrated the neurotoxicity of heavy metals and sleeping is heavily regulated and coordinated by nervous system. Based on available epidemiological studies, the paper reviewed the effects of heavy metals on sleep status of occupational and non-occupational (general adults as well as infants and adolescents) populations. In addition, it presented the associated mechanisms in terms of sleep-wake cycle and sleep-related neurochemicals.

     

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