张善宇, 姚谦, 施蓉, 田英. 全氟与多氟烷基物质的生殖毒性研究进展[J]. 环境与职业医学, 2021, 38(10): 1161-1168. DOI: 10.13213/j.cnki.jeom.2021.21082
引用本文: 张善宇, 姚谦, 施蓉, 田英. 全氟与多氟烷基物质的生殖毒性研究进展[J]. 环境与职业医学, 2021, 38(10): 1161-1168. DOI: 10.13213/j.cnki.jeom.2021.21082
ZHANG Shanyu, YAO Qian, SHI Rong, TIAN Ying. Research progress on reproductive toxicity of per- and polyfluoroalkyl substances[J]. Journal of Environmental and Occupational Medicine, 2021, 38(10): 1161-1168. DOI: 10.13213/j.cnki.jeom.2021.21082
Citation: ZHANG Shanyu, YAO Qian, SHI Rong, TIAN Ying. Research progress on reproductive toxicity of per- and polyfluoroalkyl substances[J]. Journal of Environmental and Occupational Medicine, 2021, 38(10): 1161-1168. DOI: 10.13213/j.cnki.jeom.2021.21082

全氟与多氟烷基物质的生殖毒性研究进展

Research progress on reproductive toxicity of per- and polyfluoroalkyl substances

  • 摘要:

    全氟与多氟烷基物质(PFAS)是一类用于工业生产并广泛存在于环境中的氟代有机化合物,是一类环境内分泌干扰物,对人体具有多种毒性作用。近年来,PFAS所产生的生殖毒性受到越来越多的关注。在男性中,PFAS与精子质量下降、睾酮水平降低有关;在女性中,PFAS与女性体内异常的性激素水平、不孕风险增加有关,还与女性不正常的生理周期有关。机制研究表明,PFAS可能通过影响下丘脑-垂体-性腺轴,干扰性激素生成,诱导生殖细胞氧化应激等途径产生生殖毒性。本文主要从人群流行病学、动物研究及其机制方面概述PFAS的生殖毒性,有助于进一步了解其毒性效应及机制。

     

    Abstract:

    Per- and polyfluoroalkyl substances (PFAS) are a class of fluorinated organic compounds that are used in industrial production and widely exist in the environment. As one of the environmental endocrine disruptors, PFAS have a variety of toxicities. In recent years, more and more studies focus on its reproductive toxicity. In men, PFAS are related to decreased sperm quality and testosterone levels. In women, PFAS are related to abnormal levels of sex hormones, increased risks of infertility, and irregular menstrual cycle. Mechanism studies have shown that PFAS may produce reproductive toxicity through affecting hypothalamic-pituitary-gonadal axis, interfering with sex hormone synthesis, and inducing oxidative stress in germ cells. This article summarized the reproductive toxicity of PFAS from the aspects of epidemiological, laboratory animal, and related mechanism studies, aiming to further understand its toxic effects and mechanisms.

     

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