刘纯, 周星宇, 杨世榕, 李仲伟, 贾莹. 氟骨损害相关信号通路及其交互调控作用[J]. 环境与职业医学, 2021, 38(7): 794-800. DOI: 10.13213/j.cnki.jeom.2021.20607
引用本文: 刘纯, 周星宇, 杨世榕, 李仲伟, 贾莹. 氟骨损害相关信号通路及其交互调控作用[J]. 环境与职业医学, 2021, 38(7): 794-800. DOI: 10.13213/j.cnki.jeom.2021.20607
LIU Chun, ZHOU Xingyu, YANG Shirong, LI Zhongwei, JIA Ying. Mechanism and cross-talk of signaling pathways associated with bone damage in fluorosis[J]. Journal of Environmental and Occupational Medicine, 2021, 38(7): 794-800. DOI: 10.13213/j.cnki.jeom.2021.20607
Citation: LIU Chun, ZHOU Xingyu, YANG Shirong, LI Zhongwei, JIA Ying. Mechanism and cross-talk of signaling pathways associated with bone damage in fluorosis[J]. Journal of Environmental and Occupational Medicine, 2021, 38(7): 794-800. DOI: 10.13213/j.cnki.jeom.2021.20607

氟骨损害相关信号通路及其交互调控作用

Mechanism and cross-talk of signaling pathways associated with bone damage in fluorosis

  • 摘要:

    慢性氟中毒是一种慢性全身疾病,骨相损害主要表现为氟骨症和氟牙症。氟或氟化物通过对信号通路的多个阶段产生影响,打破骨转换动态平衡,诱导成骨/破骨细胞的分化和凋亡。本综述重点介绍了五条途径:刺猬信号、Wnt/β-连环蛋白、Notch、核因子-κB受体激活子/核因子κB受体活化因子配体/骨保护素、甲状旁腺激素通路,以及这些信号通路网络中起关键作用的连接点,发现氟能够干预信号通路中的分子活性,对骨转换进行调控,并且通路之间相互协同或拮抗,维持氟中毒环境下的骨形成和骨破坏。

     

    Abstract:

    Chronic fluorosis is a kind of chronic systemic disease. Bone damage in fluorosis is mainly manifested as skeletal fluorosis and dental fluorosis. Fluorine or fluoride can break the dynamic balance of bone turnover and induce the differentiation and apoptosis of osteoblasts/osteoclasts by affecting mutiple stages of signaling pathways. This review highlighted the roles of five signaling pathways: hedgehog, Wnt/β-catenin, Notch, receptor activator of nuclear factorkappa B/receptor activator of nuclear factor-kappa B ligand/osteoprotegerin, and parathyroid hormone (PTH), and the identified keynodes in these signaling pathways. It was found that fluoride can interfere with the molecular activity of selected signaling pathways, regulate bone turnover, and maintain bone formation and bone destruction during fluorosis through the synergistic or antagonistic action of pathways.

     

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