乌鲁木齐市母婴多环芳烃负荷水平及关系：基于某三甲医院的调查
Relationship between polycyclic aromatic hydrocarbons loads of pregnant women and newborns in a Class-A tertiary hospital in Urumqi
-
摘要:
背景 乌鲁木齐市多环芳烃污染问题较为严重，已有研究多为环境中多环芳烃的测定，缺乏人群研究尤其是母婴多环芳烃暴露的研究。
目的 评价乌鲁木齐市孕产妇及其新生儿多环芳烃负荷水平，探索两者之间的关系。
方法 纳入2019年1月1日—12月31日在乌鲁木齐市某综合性三甲医院分娩的孕产妇200人，收集孕产妇外周静脉血及其新生儿脐血，共400份血液样本，采用气相色谱-质谱联用法检测16种多环芳烃（萘；苊烯；苊；芴；菲；蒽；荧蒽；芘；苯并
a 芘；䓛；苯并g ，h ，i 芘；苯并a 蒽；苯并b 荧蒽；苯并k 荧蒽；茚并1 ，2 ，3 -cd 芘；二苯并a ，h 蒽）的含量，采用Spearman秩相关分析孕产妇及新生儿多环芳烃暴露水平的相关性。结果 孕产妇外周静脉血中16种PAHs检出率最高为苊和䓛，其次为苯并
a 芘、芴和菲，最低为苯并a 蒽（95.5%、94.5%、83.0%）；检出浓度最大值最高为苊，其次为芴，最低为茚并1 ，2 ，3 -cd 芘（23.39、13.36、0.99 μg·L-1）；检出浓度中位数（M ）最高值为苊，其次为芴，最低为芘（5.48、3.05、0.14 μg·L-1）。新生儿脐带血中16种PAHs检出率最高为萘，其次为苊，最低为苯并b 荧蒽（97.5%、96.0%、79.0%）；检出浓度最大值前三位为苊、芴、苯并g ，h ，i 芘（10.11、9.97、0.91μg·L-1），中位数（M ）前三位为苊、芴和苯并a 芘（4.55、3.23、0.08μg·L-1）。苊烯检出最小值低于0.01 μg·L-1。新生儿脐血中苯并k 荧蒽、芴与孕产妇外周静脉血中该物质浓度相关（r =0.206，r =0.162，P < 0.05）。结论 乌鲁木齐市孕产妇及新生儿血中可检测出多种多环芳烃，而且孕妇与新生儿体内的多种多环芳烃浓度存在弱相关关系，提示孕妇多环芳烃暴露可能会导致新生儿体内的多环芳烃负荷水平增加，从而影响新生儿健康。
Abstract:Background Polycyclic aromatic hydrocarbons (PAHs) pollution is a serious problem in Urumqi. Most studies determine environmental PAHs, and there lacks population studies, especially on the exposure of mothers and infants to PAHs.
Objective This study aims to evaluate the PAHs loads of pregnant women and their newborns, and to explore the relationship between them.
Methods From January 1 to December 31, 2019, a total of 200 pregnant women who delivered in a Class-A tertiary general hospital in Urumqi were enrolled in the study. Their peripheral venous blood samples (
n =200) and their newborns' cord blood samples (n =200) were collected to detect 16 kinds of PAHs (naphthalene, acenaphthylene, acenaphthene, fluorene, phenanthrene, anthracene, fluoranthene, pyrene, benzoa pyrene, chrysene, benzog ,h ,i pyrene, benzoa anthracene, benzob fluoranthene, benzok fluoranthene, indeno1 ,2 ,3 -cd pyrene, and dibenzoa ,h anthracene) by gas chromatography-mass spectrometry. Spearman rank correlation analysis was used to analyze the correlation of PAHs exposure levels in pregnant women and their newborns.Results Among the selected 16 PAHs in maternal peripheral venous blood, acenaphthene and chrysene had the highest positive rates (both 95.5%), followed by benzoapyrene, fluorene, and phenanthrene (all 94.5%), and the lowest was benzoaanthracene (83.0%); acenaphthene had the highest maximum concentration, followed by fluorene, and indeno
1 ,2 ,3 -cd pyrene had the lowest (23.39, 13.36, and 0.99 μg·L-1, respectively); acenaphthene had the highest median concentration (M ), followed by fluorene, and pyrene had the lowest (5.48, 3.05, and 0.14 μg·L-1, respectively). Among the selected 16 PAHs in neonatal umbilical cord blood, naphthalene had the highest positive rate, followed by acenaphthene, and benzob fluoranthene had the lowest (97.5%, 96.0%, and 79.0%, respectively); acenaphthene, fluorene, benzog ,h ,i pyrene had the highest maximum concentrations (10.11, 9.97, 0.91 μg·L-1, respectively); acenaphthene, fluorene, and benzoa pyrene had the highest median concentrations (M ) (4.55, 3.23, 0.08 μg·L-1, respectively). The minimum concentration of acenaphthylene was lower than 0.01 μg·L-1. Benzok fluoranthene and fluorene concentrations in the cord blood of newborns were correlated with the concentrations in the peripheral venous blood of pregnant women (r =0.206,r =0.162,P < 0.05).Conclusion A variety of PAHs are detected in the blood of pregnant women and newborns in Urumqi, and there are weak correlations between pregnant women and their newborns, suggesting that the PAHs exposure of pregnant women may cause PAHs loads in newborns and affect their health.
下载:
