孙玮奇, 周志俊. 致血睾屏障损伤的化学物及其作用机制研究进展[J]. 环境与职业医学, 2020, 37(8): 821-825. DOI: 10.13213/j.cnki.jeom.2020.20062
引用本文: 孙玮奇, 周志俊. 致血睾屏障损伤的化学物及其作用机制研究进展[J]. 环境与职业医学, 2020, 37(8): 821-825. DOI: 10.13213/j.cnki.jeom.2020.20062
SUN Wei-qi, ZHOU Zhi-jun. Research progress on chemicals and their mechanisms of action that cause blood-testis barrier injury[J]. Journal of Environmental and Occupational Medicine, 2020, 37(8): 821-825. DOI: 10.13213/j.cnki.jeom.2020.20062
Citation: SUN Wei-qi, ZHOU Zhi-jun. Research progress on chemicals and their mechanisms of action that cause blood-testis barrier injury[J]. Journal of Environmental and Occupational Medicine, 2020, 37(8): 821-825. DOI: 10.13213/j.cnki.jeom.2020.20062

致血睾屏障损伤的化学物及其作用机制研究进展

Research progress on chemicals and their mechanisms of action that cause blood-testis barrier injury

  • 摘要:

    血睾屏障(BTB)是哺乳动物体内最牢固的血液-组织屏障之一,其特殊的结构使其能够防止精子作为抗原的自身免疫反应,阻止有害物质进入曲细精管,其创造的稳定生精内环境对于维持雄性正常生殖功能至关重要。有关BTB的研究在雄性生殖毒理学领域属于前沿热点。关注可致BTB损伤的化学物及其作用机制对于研究外源性化学物诱导的雄性生殖损伤具有重要意义,可为预防外源性化学物所致雄性生殖损害以及新型避孕药物的研发提供理论依据。本文介绍了BTB的结构组成、生理功能及其在生精过程中维持内环境稳定时的动态变化,回顾了可引起BTB损伤的化学物种类及其毒作用特点,总结了化学物致BTB损伤的可能机制,并基于以上内容指出了现有研究中存在的不足及未来研究的方向,旨在为后续研究提供科学理论基础及更多开创性思路。

     

    Abstract:

    Blood-testis barrier (BTB) is one of the strongest blood-tissue barriers in mammals, and its special structure allows it to prevent sperms from autoimmune reactions as antigens and prevent harmful substances from entering the seminiferous tubules. The stable spermatogenic environment created by BTB is essential for maintaining male reproductive function. Research on BTB is a hot frontier in the field of male reproductive toxicology. Focusing on chemicals that can cause BTB injury and their mechanisms of action is of great significance for studying male reproductive damage induced by exogenous chemicals, and can provide a theoretical basis for the prevention of male reproductive damage caused by exogenous chemicals and the research and development of new contraceptives. This article introduced the structure and physiological function of BTB and its dynamic changes in maintaining stable internal environment during spermatogenesis, reviewed the chemicals that can cause BTB injury and their toxic characteristics, and summarized the possible mechanisms of action of BTB injury caused by chemicals. Based on the above information, the deficiencies in existing studies and the prospects for future research were put forward, aiming to provide scientific theoretical foundations and more pioneering ideas for subsequent research.

     

/

返回文章
返回