谢毓佳, 周芸, 马继轩, 樊烈阳, 叶子, 王冬明, 陈卫红. Wnt信号通路在空气污染致气道上皮损伤及其修复中的作用研究进展[J]. 环境与职业医学, 2020, 37(3): 291-297. DOI: 10.13213/j.cnki.jeom.2020.19603
引用本文: 谢毓佳, 周芸, 马继轩, 樊烈阳, 叶子, 王冬明, 陈卫红. Wnt信号通路在空气污染致气道上皮损伤及其修复中的作用研究进展[J]. 环境与职业医学, 2020, 37(3): 291-297. DOI: 10.13213/j.cnki.jeom.2020.19603
XIE Yu-jia, ZHOU Yun, MA Ji-xuan, FAN Lie-yang, YE Zi, WANG Dong-ming, CHEN Wei-hong. Advances on role of Wnt signaling pathway in airway epithelial damage induced by air polluton and its repair[J]. Journal of Environmental and Occupational Medicine, 2020, 37(3): 291-297. DOI: 10.13213/j.cnki.jeom.2020.19603
Citation: XIE Yu-jia, ZHOU Yun, MA Ji-xuan, FAN Lie-yang, YE Zi, WANG Dong-ming, CHEN Wei-hong. Advances on role of Wnt signaling pathway in airway epithelial damage induced by air polluton and its repair[J]. Journal of Environmental and Occupational Medicine, 2020, 37(3): 291-297. DOI: 10.13213/j.cnki.jeom.2020.19603

Wnt信号通路在空气污染致气道上皮损伤及其修复中的作用研究进展

Advances on role of Wnt signaling pathway in airway epithelial damage induced by air polluton and its repair

  • 摘要:

    空气污染对呼吸系统的损害受到广泛关注,空气污染物主要通过呼吸道进入机体,可通过氧化应激和炎性反应引起呼吸系统损伤。气道及肺泡上皮是呼吸系统抵御空气污染的首要防线,具有正常修复能力的气道上皮可及时修复污染物引起的损伤从而维持呼吸系统正常功能,而上皮修复能力改变或异常被认为是引起呼吸系统进一步损伤,甚至疾病的关键。既往研究显示Wnt通路参与了慢性阻塞性肺病及哮喘等多种呼吸系统疾病的发生和发展。文献报道Wnt通路是平衡细胞自我更新和损伤修复的关键性通路,可分为经典Wnt/β-catenin通路与非经典Wnt通路,两条通路的作用不同。经典Wnt通路参与维持上皮完整性并且促进气道上皮损伤的修复;受空气污染物刺激所释放的Wnt5a可激活非经典Wnt通路,引起机体炎性反应进而损伤气道上皮,并可通过抑制经典Wnt通路使气道上皮修复能力减弱。因此,两条Wnt通路同时参与气道上皮修复过程,维持修复平衡,其失衡可能引发相关呼吸系统疾病。本文综述目前关于Wnt信号通路在空气污染致气道上皮损伤及其修复中作用的最近研究进展,为空气污染所致呼吸系统疾病的防治提供相关的依据。

     

    Abstract:

    The adverse effect of air pollution on respiratory system has raised public concern. In general, respiratory tract is the major route of air pollutant into the human body, accompanying with oxidatve stress and inflammatory response. As the frst line of defense against air pollutants, a normal functioning airway epithelium can repair the damage caused by air pollutants immediately to maintain respiratory health. Alteration or dysfunction of the epithelial repair ability might link to further respiratory damage and even respiratory disease. The Wnt signaling pathway partcipates in the development and progression of several respiratory diseases such as chronic obstructve pulmonary disease (COPD) and asthma. Previous studies have reported that it is a critcal pathway related to cell self-renewal and respiratory damage and repair, and includes canonical Wnt/β-catenin pathway and non-canonical Wnt pathway, two pathways with different functions. The canonical Wnt pathway participates in cell adhesion to maintain the integrity of the airway epithelium and to promote epithelial repair; the Wnt5a release stmulated by air pollutants can cause inflammaton by actvatng the non-canonical Wnt pathway, and also reduce epithelium repair capacity through inhibitng the canonical Wnt pathway. Both pathways partcipate in the process of epithelium repair, and imbalance of epithelial repair process may lead to related respiratory diseases. This artcle comprehensively reviewed current research on the role of Wnt signaling pathway in the airway epithelial damage induced by air polluton and epithelial repair, aiming to provide insights for the preventon and control of respiratory diseases induced by air polluton.

     

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