徐薇, 马宝慧. 氟中毒对心肌组织的影响及相关信号通路变化[J]. 环境与职业医学, 2019, 36(5): 506-510. DOI: 10.13213/j.cnki.jeom.2019.18600
引用本文: 徐薇, 马宝慧. 氟中毒对心肌组织的影响及相关信号通路变化[J]. 环境与职业医学, 2019, 36(5): 506-510. DOI: 10.13213/j.cnki.jeom.2019.18600
XU Wei, MA Bao-hui. Effects of fluorosis on myocardial tissues and related signaling pathway changes[J]. Journal of Environmental and Occupational Medicine, 2019, 36(5): 506-510. DOI: 10.13213/j.cnki.jeom.2019.18600
Citation: XU Wei, MA Bao-hui. Effects of fluorosis on myocardial tissues and related signaling pathway changes[J]. Journal of Environmental and Occupational Medicine, 2019, 36(5): 506-510. DOI: 10.13213/j.cnki.jeom.2019.18600

氟中毒对心肌组织的影响及相关信号通路变化

Effects of fluorosis on myocardial tissues and related signaling pathway changes

  • 摘要: 氟是一种常见的微量元素,参与人体生命活动的调节。人体每日摄入适量的氟,可促进牙齿和骨骼的发育,预防龋齿,也对神经系统的传导有一定的意义。但长期摄入过量的氟化物会对机体不同的器官、系统产生不利影响,尤其是心血管系统。慢性氟中毒是我国常见的地方病之一。长期摄入过量的氟化物,可导致心肌的形态结构与功能发生不同程度的损伤,使相关信号通路表达异常,因此探究氟中毒致心肌相关信号通路的变化对预防和治疗慢性氟中毒具有重要的意义。线粒体途径是由多基因参与、多条信号通路相互影响的细胞凋亡的主要途径。氧化应激在氟化物诱导的心肌损伤中起重要作用。本文主要综述了氟中毒对心肌组织的影响,并从氧化应激、细胞凋亡方面阐述了氟中毒致心肌损伤的相关信号通路变化,为氟中毒的预防与治疗提供一定的理论依据。

     

    Abstract: Fluorine is a common trace element that participates in the regulation of vital activities in human body. Proper intake of fluoride promotes the development of teeth and bones, prevents dental caries, and also benefits the conduction in the nervous system. However, long-term intake of excessive fluoride adversely affects various organ systems, especially the cardiovascular system. Chronic fluorosis is one common endemic disease in China. Long-term intake of excessive fluoride can cause different degrees of damage to the morphological structure and function of myocardium, and abnormal expressions of related signaling pathways. Therefore, exploring the changes of related signaling pathways in myocardial caused by fluorosis is important for the prevention and treatment of chronic fluorosis. The mitochondrial pathway of cell apoptosis involves multiple genes and signaling pathways. Oxidative stress plays an important role in fluoride-induced myocardial damage. This papaer reviewed the effects of fluorosis on myocardial tissues and discussed the changes of signaling pathways related to myocardial injury induced by fluorosis from the perspectives of oxidative stress and cell apoptosis, aiming to provide a theoretical basis for the prevention and treatment of fluorosis.

     

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