梁婷婷, 米辰炀, 谢嘉渝, 许仲妍, 陈维娜, 张豆豆, 张慧东. lncRNA在女性生殖系统恶性肿瘤中的功能和作用机制[J]. 环境与职业医学, 2019, 36(3): 232-237, 241. DOI: 10.13213/j.cnki.jeom.2019.18468
引用本文: 梁婷婷, 米辰炀, 谢嘉渝, 许仲妍, 陈维娜, 张豆豆, 张慧东. lncRNA在女性生殖系统恶性肿瘤中的功能和作用机制[J]. 环境与职业医学, 2019, 36(3): 232-237, 241. DOI: 10.13213/j.cnki.jeom.2019.18468
LIANG Ting-ting, MI Chen-yang, XIE Jia-yu, XU Zhong-yan, CHEN Wei-na, ZHANG Dou-dou, ZHANG Hui-dong. Functions and mechanisms of lncRNA in malignant tumors of female reproductive system[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 232-237, 241. DOI: 10.13213/j.cnki.jeom.2019.18468
Citation: LIANG Ting-ting, MI Chen-yang, XIE Jia-yu, XU Zhong-yan, CHEN Wei-na, ZHANG Dou-dou, ZHANG Hui-dong. Functions and mechanisms of lncRNA in malignant tumors of female reproductive system[J]. Journal of Environmental and Occupational Medicine, 2019, 36(3): 232-237, 241. DOI: 10.13213/j.cnki.jeom.2019.18468

lncRNA在女性生殖系统恶性肿瘤中的功能和作用机制

Functions and mechanisms of lncRNA in malignant tumors of female reproductive system

  • 摘要: 长链非编码RNA(long non-coding RNA,lncRNA)是指长度超过200个核苷酸,无典型开放阅读框,且不能编码蛋白质的RNA转录本。lncRNA在机体的转录、翻译和RNA可变剪切等生命过程中发挥着重要的生理作用。lncRNA在机体中通过分子引导的方式或作为分子诱饵、分子信号及分子支架发挥其功能。近些年来,大量的研究表明,lncRNA的异常表达与女性生殖系统恶性肿瘤密切相关。基于国内外最新研究,本文主要总结了lncRNA在卵巢癌、宫颈癌和子宫内膜癌中的作用机制,简要介绍了lncRNA在绒毛膜癌、外阴癌等其他女性生殖系统恶性肿瘤中的作用。lncRNA通过各种机制在癌症进展中扮演着癌基因或抑癌基因的角色。随着研究方法和技术的发展,lncRNA作为可靠的生物标志和新的癌症治疗靶点的潜力也将得到进一步开发,从而为保障女性生殖健康提供新思路和新方法。

     

    Abstract: Long non-coding RNA (lncRNA) refers to an RNA transcript that is more than 200 nucleotides in length, has no typical open reading frame, and cannot encode a protein. It plays an important physiological role in biological processes such as transcription, translation, and RNA variability. It functions in the body by molecular guidance or as a molecular bait, molecular signal, and molecular scaffold. In recent years, a large number of studies have shown that lncRNA abnormal expression is closely related to female reproductive malignancies. Based on the latest research at home and abroad, we summarized the mechanisms of lncRNA in ovarian cancer, cervical cancer, and endometrial cancer, and briefly introduced the roles of lncRNA in other female reproductive malignancies such as endometrial cancer and vulvar cancer. It functions as an oncogene or tumor suppressor gene in cancer progression through various mechanisms. With the development of research methods and techniques, the potentials of lncRNA as a reliable biomarker and a new cancer therapeutic target will also be further developed, aiming to provide new ideas and methods to protect female reproductive health.

     

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