室内环境污染对变应性鼻炎发病影响的meta分析
Effects of indoor environmental pollution on allergic rhinitis occurrence: A meta analysis
-
摘要:
目的 通过meta分析评估室内环境污染导致人群出现变应性鼻炎（AR）临床症状（AR发病）的危险性。
方法 检索PubMed、ScienceDirect、Google Scholar等数据库，文献发表时间为2003年1月1日-2017年12月31日，纳入研究室内环境污染与AR发病关联的文献，并用Combie横断面研究评价工具对研究质量予以评定。以研究最广泛、具有代表性的室内环境污染——环境烟草烟雾（ETS）、宠物及霉菌，与一年内AR发病的OR及其95%置信区间（CI）作为效应量，采用Stata-MP 14.1软件进行统计学数据分析和图形绘制。
结果 最终纳入16篇相对高质量的横断面研究。10篇报道结果显示ETS的长时间暴露会导致AR发病风险增高（OR合并=1.086；95%CI：1.039~1.135；P < 0.001）；7篇文献结果显示宠物会诱发AR发病（OR合并=1.175；95%CI：1.001~1.378；P=0.048）；9篇文献显示室内环境中霉菌的暴露会造成AR发病风险上升（OR合并=1.331；95%CI：1.172~1.512；P < 0.001）。
结论 ETS、宠物及霉菌暴露均是AR发病的危险因素。室内环境污染的控制与患者健康教育是预防AR发病的关键。
Abstract:Objective To assess the risk of clinical symptoms of allergic rhinitis (AR occurrence) contributed by indoor environmental pollution.
Methods Published studies on the association between indoor environmental pollution and AR occurrence were searched in PubMed, ScienceDirect, and Google Scholar databases from January 1, 2003 to December 31, 2017, and the Combie cross-sectional study evaluation tool was used to evaluate the quality of included literatures. The OR and 95% confidence interval (CI) of AR occurrence manifested within one year of exposure to the most widely studied and representative indoor environmental pollution, such as environmental tobacco smoke (ETS), pets, and molds, were analyzed in Stata-MP 14.1 software to generate plots.
Results Finally 16 qualified cross-sectional studies were included. Specifically, 10 studies showed that prolonged exposure to ETS would increase the risk of AR occurrence (ORcombined=1.086, 95%CI:1.039-1.135; P < 0.001); 7 studies showed that exposure to pets would increase the risk of AR occurrence (ORcombined=1.175, 95%CI:1.001-1.378; P=0.048); 9 articles showed that exposure to indoor molds would increase the risk of AR occurrence (ORcombined=1.331, 95%CI:1.172-1.512; P < 0.001).
Conclusion Exposures to ETS, pet, and molds are risk factors of AR occurrence. Indoor environmental pollution control and health education for patients are key to AR prevention.
下载:
