张锋, 潘丽萍, 丁恩民, 窦建瑞, 蔡璐, 朱宝立. 职业人群草甘膦内外暴露指标的相关性[J]. 环境与职业医学, 2018, 35(11): 990-995. DOI: 10.13213/j.cnki.jeom.2018.18335
引用本文: 张锋, 潘丽萍, 丁恩民, 窦建瑞, 蔡璐, 朱宝立. 职业人群草甘膦内外暴露指标的相关性[J]. 环境与职业医学, 2018, 35(11): 990-995. DOI: 10.13213/j.cnki.jeom.2018.18335
ZHANG Feng, PAN Li-ping, DING En-min, DOU Jian-rui, CAI Lu, ZHU Bao-li. Relationships between internal and external exposure indicators of glyphosate in occupational workers[J]. Journal of Environmental and Occupational Medicine, 2018, 35(11): 990-995. DOI: 10.13213/j.cnki.jeom.2018.18335
Citation: ZHANG Feng, PAN Li-ping, DING En-min, DOU Jian-rui, CAI Lu, ZHU Bao-li. Relationships between internal and external exposure indicators of glyphosate in occupational workers[J]. Journal of Environmental and Occupational Medicine, 2018, 35(11): 990-995. DOI: 10.13213/j.cnki.jeom.2018.18335

职业人群草甘膦内外暴露指标的相关性

Relationships between internal and external exposure indicators of glyphosate in occupational workers

  • 摘要: 目的 分析职业人群接触草甘膦的时间加权浓度(TWA)与尿中草甘膦及其代谢产物氨甲基膦酸(AMPA)浓度的关系。

    方法 选择5家草甘膦生产企业中134名职业性接触草甘膦工人和152名不接触工人作为研究对象。对接触工人采用个体检测方法,计算其草甘膦接触的TWA值。对研究对象开展问卷调查和尿样采集,使用气相色谱-质谱联用法检测其尿中草甘膦及其代谢产物AMPA的含量。使用非参数检验比较尿中草甘膦及AMPA浓度。采用相关性检验分析工人接触草甘膦的TWA值与尿中草甘膦、AMPA浓度的相关性。

    结果 各岗位接触草甘膦TWA值范围为 < 0.02~34.58 mg/m3。接触组人群尿中草甘膦及AMPA检出率分别为86.6%、81.3%,质量浓度范围分别为 < 0.020~17.202、 < 0.010~2.730 mg/L,中位数分别为0.292、0.068 mg/L。接触组尿中草甘膦、AMPA质量浓度均高于对照组(P < 0.05)。接触组人群尿中草甘膦、AMPA浓度与接触的草甘膦TWA值呈正相关(r=0.755、0.682,P < 0.01);尿中草甘膦与AMPA浓度之间呈正相关(r=0.472,P < 0.01)。

    结论 工人尿中草甘膦、AMPA浓度与工作场所空气中草甘膦TWA值相关。

     

    Abstract: Objective To evaluate the relationships between time-weighted average (TWA) of glyphosate and urinary concentrations of glyphosate and its metabolite aminmethyl phosphonic acid (AMPA) in selected occupational groups.

    Methods A total of 134 exposure workers and 152 control workers from five glyphosat manufacturers were selected as study subjects. Glyphosate in workplace air was sampled by using personal sampler to calculate TWA. The concentrations of glyphosate and its metabolite AMPA in urine of the subjects were detected by gas chromatography-mass spectrometry. Urinary concentrations of glyphosate and AMPA were compared by nonparametric test. The relationships between TWA of glyphosate and urinary concentrations of glyphosate and AMPA were evaluated by correlation analysis.

    Results The estimated TWA values of glyphosate of various posts in the exposure group were from < 0.02 mg/m3 to 34.58 mg/m3. The positive rates of glyphosate and AMPA in urine of the exposure workers were 86.6% and 81.3% respectively; the urinary concentrations were < 0.020-17.202 mg/L and < 0.010-2.730 mg/L respectively; the medians were 0.292 mg/L and 0.068 mg/L respectively. The concentrations of glyphosate and AMPA in the exposure group were higher than those in the control group (P < 0.05). Urinary concentrations of glyphosate and AMPA were positively associated with TWA of glyphosate of the exposure workers (r=0.755, 0.682, P < 0.01) respectively; also, there was a positive association between the urinary concentrations of glyphosate and AMPA (r=0.472, P < 0.01).

    Conclusion The concentrations of glyphosate and AMPA in urine of workers have correlations with the TWA of glyphosate in workplace air.

     

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