王俊东, 王依闻, 高永玲, 郑海霞, 周义军, 张妍, 施蓉, 田英. 山东莱州湾出生队列孕妇及幼儿有机磷农药暴露水平[J]. 环境与职业医学, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722
引用本文: 王俊东, 王依闻, 高永玲, 郑海霞, 周义军, 张妍, 施蓉, 田英. 山东莱州湾出生队列孕妇及幼儿有机磷农药暴露水平[J]. 环境与职业医学, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722
WANG Jun-dong, WANG Yi-wen, GAO Yong-ling, ZHENG Hai-xia, ZHOU Yi-jun, ZHANG Yan, SHI Rong, TIAN Ying. Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722
Citation: WANG Jun-dong, WANG Yi-wen, GAO Yong-ling, ZHENG Hai-xia, ZHOU Yi-jun, ZHANG Yan, SHI Rong, TIAN Ying. Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort[J]. Journal of Environmental and Occupational Medicine, 2018, 35(5): 423-427. DOI: 10.13213/j.cnki.jeom.2018.17722

山东莱州湾出生队列孕妇及幼儿有机磷农药暴露水平

Organophosphate pesticides exposure levels in pregnant women and children from Laizhou Bay Birth Cohort

  • 摘要: 目的 测定山东莱州湾出生队列中孕妇及24月龄幼儿的有机磷农药(organophosphate pesticides,OPs)暴露水平。

    方法 依托于山东莱州湾出生队列研究,对436名孕妇进行问卷调查,收集孕妇产前随机尿,并随访至24个月,收集239份24月龄幼儿的随机尿。采用气相色谱-质谱串联法检测孕妇及幼儿尿液中6种OPs非特异性代谢产物,即二乙基二硫代磷酸酯(diethyldithiophosphate,DEDTP)、二乙基硫代磷酸酯(diethylthiophosphate,DETP)、磷酸二乙酯(diethylphosphate,DEP)、二甲基二硫代磷酸酯(dimethyldithiophosphate,DMDTP)、二甲基硫代磷酸酯(dimethylthiophosphate,DMTP)、磷酸二甲酯(dimethylphosphate,DMP)。采用Spearman相关分析孕妇及幼儿尿液中OPs非特异性代谢产物水平的相关性。

    结果 436份孕妇尿样中DEP、DETP、DMP、DMTP的水平分别为11.41、1.93、21.42、2.24μg/g(经尿肌酐校正),239份幼儿尿样中DEP、DETP、DMP、DMTP的水平分别为16.65、3.95、38.68、3.48 μg/g(经尿肌酐校正)。仅发现孕妇与幼儿尿液中的DEP水平呈负相关(r=-0.149,P=0.021)。

    结论 山东省渤海莱州湾出生队列中的孕妇及幼儿OPs暴露水平较高,应引起重视。

     

    Abstract: Objective To determine the organophosphate pesticides (OPs) exposure levels in pregnant women and children at 24 months of age from Laizhou Wan (Bay) Birth Cohort (LWBC) in Shandong.

    Methods The present study was a part of a longitudinal birth cohort study in the southern coastal area of Laizhou Wan (Bay) of the Bohai Sea, Shandong Province, China. Pregnant women (n=436) were recruited to complete a questionnaire survey and to collect random spot urine samples. They were followed up until their children were 24 months of age to collect children's urine samples (n=239). Non-specific OPs metabolites, including diethyldithiophosphate (DEDTP), diethylthiophosphate (DETP), diethylphosphate (DEP), dimethyldithiophosphate (DMDTP), dimethylthiophosphate (DMTP), and dimethylphosphate (DMP), in mothers' and children's urine samples were detected by gas chromatography-mass spectrometry. Correlations of the non-specific OPs metabolites mother's and children's urine samples were analyzed by Spearman correlation analysis.

    Results The creatinine-adjusted levels in 436 maternal urine samples were 11.41 μg/g for DEP, 1.93 μg/g for DETP, 21.42 μg/g for DMP, and 2.24 μg/g for DMTP, respectively. The levels in 239 twenty-four-month-old children's urine samples were 16.65 μg/g for DEP, 3.95 μg/g for DETP, 38.68 μg/g for DMP, and 3.48 μg/g for DMTP, respectively. A negative correlation was found between DEP levels in maternal and children's urine samples (r=-0.149, P=0.021).

    Conclusion The pregnant women and children from the Laizhou Bay Birth Cohort show high exposure levels of OPs, requiring concerns.

     

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