尘肺病患者经纤维支气管镜大容量肺灌洗残余量预测模型初探
Preliminary Study on Prediction Model of Bronchoalveolar Lavage Fluid Residual Volume in Pneumoconiosis Patients by Whole Lung Lavage with Transbronchoscope
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摘要:
目的 通过建立尘肺病患者经纤维支气管镜大容量肺灌洗残余量预测模型,为筛选尘肺肺灌洗对象及初步预测灌洗疗效提供参考。 方法 收集238例尘肺病患者,经纤维支气管镜大容量肺灌洗术,分析残余量与患者病情分期、灌洗量、肺功能、身高、体重、体质指数的关系,建立多元线性回归模型,筛选影响灌洗残余量的主要影响因素。 结果 经纤维支气管镜大容量肺灌洗术中残余量与病情分期无关,不同期别尘肺灌洗量及残余量比较,差异无统计学意义(P > 0.05),灌洗量、用力肺活量(FVC%)及50%肺活量最大呼气流量(MEF50)是残余量的影响因素。 结论 本研究建立的经纤维支气管镜大容量肺灌洗残余量预测模型,可初步筛选肺灌洗病人并预测肺灌洗疗效。 Abstract:Objective To establish a bronchoalveolar lavage fluid residual volume prediction model for pneumoconiosis patients by large volume whole lung lavage with transbronchoscope, and provide reference for screening potential patients for lung la vage and preliminary forecast of lavage treatment efficacy. Methods A total of 238 patients with pneumoconiosis were enrolled in this study and received large volume whole lung lavage via transbronchoscope. The associations of residual volume with patient's pathological stage, lavage volume, lung function, height, body weight, and body mass index were analyzed by multivariate linear regression model. Results The residual volume of large volume whole lung lavage via transbronchoscope showed no correlation with pneumoconiosis stage and no statistically significant difference across pneumoconiosis stages (P > 0.05). Lavage volume, forced vital capacity (FVC%), and maximal expiratory flow at 50% respiratory function (MEF50) were the factors affecting residual volume. Conclusion The prediction model of residual volume of bronchoalveolar lavage fluid in pneumoconiosis patients by whole lung lavage via transbronchoscope could preliminarily screen patients for lung lavage and predict lung lavage curative effect.
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