黎小飞, Eliseo GUALLAR, Ruoxi LIN, Yiyi ZHANG, 钟秋安. 美国一般人群尿镉水平与心电图改变的关系[J]. 环境与职业医学, 2015, 32(3): 216-221. DOI: 10.13213/j.cnki.jeom.2015.14461
引用本文: 黎小飞, Eliseo GUALLAR, Ruoxi LIN, Yiyi ZHANG, 钟秋安. 美国一般人群尿镉水平与心电图改变的关系[J]. 环境与职业医学, 2015, 32(3): 216-221. DOI: 10.13213/j.cnki.jeom.2015.14461
LI Xiao-fei , Eliseo GUALLAR , Ruoxi LIN , Yiyi ZHANG , ZHONG Qiu-an . Urine Cadmium in Association with Electrocardiographic Changes in the U.S.General Population[J]. Journal of Environmental and Occupational Medicine, 2015, 32(3): 216-221. DOI: 10.13213/j.cnki.jeom.2015.14461
Citation: LI Xiao-fei , Eliseo GUALLAR , Ruoxi LIN , Yiyi ZHANG , ZHONG Qiu-an . Urine Cadmium in Association with Electrocardiographic Changes in the U.S.General Population[J]. Journal of Environmental and Occupational Medicine, 2015, 32(3): 216-221. DOI: 10.13213/j.cnki.jeom.2015.14461

美国一般人群尿镉水平与心电图改变的关系

Urine Cadmium in Association with Electrocardiographic Changes in the U.S.General Population

  • 摘要: 目的 观察美国一般人群的尿镉水平与心电图改变的关系,了解镉暴露对心电图的影响。

    方法 利用美国第三次国家健康与营养调查(NHANES Ⅲ)中进行心电图测量,年龄 ≥ 40岁的6 889名参与者作为研究对象。采用标准十二导联心电图分析系统记录心电图参数;采用原子吸收光谱法测定尿镉含量。按性别分层,运用多元线性回归分析尿镉水平与心电图改变的关系。

    结果 尿镉平均水平为(0.7& #177;0.01)μg/g肌酐,其中男性人群平均(0.6& #177;0.02)μg/g肌酐;女性(0.8& #177;0.02)μg/g肌酐;在男性群体,尿镉水平四分位最高与最低等分相比,多因素调整的心率、PRrr间期、QTrr间期和QRS间期变化及其95% CI分别为1.72 (0.05~3.4)次/分,-3.87 (-7.3~-0.45)ms,-0.39 (-4.09~3.22)ms和-2.64 (-4.96~-0.33)ms。在女性群体,尿镉水平最高与最低等分相比,上述相应的心电图参数变化及其95% CI分别为-0.19 (-1.72~1.33)次/分,-0.09(-4.13~3.94)ms, 1.59(-1.05~4.23)ms和-1.11(-2.68~0.47)ms。

    结论 尿镉水平与美国男性一般人群的心电图改变存在一定的关联。

     

    Abstract: Objective To examine the associations of urine cadmium with electrocardiogram (ECG) changes in the U. S. general population.

    Methods We included 6 889 individuals who aged ≥ 40 years and registered to the ECG examination of the U.S. Third National Health and Nutrition Examination Survey (NHANES Ⅲ). The ECG parameters were recorded via standard 12-lead ECG analysis system, and the urine cadmium was measured by atomic absorption spectrometry. Analysis was based on cross-sectional design, and stratified by sex. We used multivariable linear regression to estimate the associations of urine cadmium concentrations with the ECG changes.

    Results The average urine cadmium levels in the overall, male, and female participants were (0.7& #177;0.01), (0.6& #177;0.02), and (0.8& #177;0.02)μg/g cretinine, respectively. The multivariable-adjusted differences in heart rate, PRrr interval, QTrr interval, and QRS interval, comparing the highest with the lowest quartile of urine cadmium, were 1.72 (95%CI:0.05, 3.4)beats/min, -3.87 (95%CI:-7.3, -0.45)ms, -0.39 (95%CI:-4.09, 3.22)ms, and -2.64 (95%CI:-4.96, -0.33)ms in the male participants, respectively. The corresponding differences were -0.19 (95%CI:-1.72, 1.33)beats/min, -0.09 (95%CI:-4.13, 3.94)ms, 1.59 (95%CI:-1.05, 4.23)ms, and -1.11 (95%CI:-2.68, 0.47)ms in the female participants, respectively.

    Conclusion Urine cadmium is associated with ECG changes in the U.S. general male population.

     

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