徐卓佳, 初荣, 梁艳闯, 张忠栋, 王雷, 王铠. 民航男性飞行员高尿酸血症及其肾脏功能早期损伤的调查[J]. 环境与职业医学, 2015, 32(4): 343-346. DOI: 10.13213/j.cnki.jeom.2015.14365
引用本文: 徐卓佳, 初荣, 梁艳闯, 张忠栋, 王雷, 王铠. 民航男性飞行员高尿酸血症及其肾脏功能早期损伤的调查[J]. 环境与职业医学, 2015, 32(4): 343-346. DOI: 10.13213/j.cnki.jeom.2015.14365
XU Zhuo-jia , CHU Rong , LIANG Yan-chuang , ZHANG Zhong-dong , WANG Lei , WANG Kai . Hyperuricemia Prevalence and Related Early Renal Injury in Male Civil Aviation Pilots[J]. Journal of Environmental and Occupational Medicine, 2015, 32(4): 343-346. DOI: 10.13213/j.cnki.jeom.2015.14365
Citation: XU Zhuo-jia , CHU Rong , LIANG Yan-chuang , ZHANG Zhong-dong , WANG Lei , WANG Kai . Hyperuricemia Prevalence and Related Early Renal Injury in Male Civil Aviation Pilots[J]. Journal of Environmental and Occupational Medicine, 2015, 32(4): 343-346. DOI: 10.13213/j.cnki.jeom.2015.14365

民航男性飞行员高尿酸血症及其肾脏功能早期损伤的调查

Hyperuricemia Prevalence and Related Early Renal Injury in Male Civil Aviation Pilots

  • 摘要: 目的 分析民航男性飞行员高尿酸血症的发病率及相关因素,同时探讨飞行员高尿酸血症与肾脏早期损伤之间的关系。

    方法 对2013年在民航总医院航空人员体检检定所体检的民航男性飞行员体检资料进行分析。用酶联免疫吸附实验检测肾脏早期损伤指标,包括尿α1-微球蛋白(α1-MG)、尿β2-微球蛋白(β2-MG)、尿胱抑素C(CysC)、尿N-乙酰β-氨基葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP),比较高尿酸与尿酸正常飞行员间的差异。

    结果 高尿酸血症者共97名,患病率为25.2%,各年龄组间高尿酸血症患病率比较,差异无统计学意义(P > 0.05)。logistic回归分析结果显示,高尿酸血症的高危因素为高BMI、高血脂、高胆红素(P值分别为0.001、0.004、0.009)。高尿酸飞行员尿α1-MG、CysC、NAG、RBP均高于尿酸正常者。

    结论 高尿酸血症是危害民航男性飞行员健康的一种严重代谢性疾病,患病率明显高于普通人群或空军飞行员,且无年龄差别。高BMI、高血脂、高胆红素为高尿酸血症的高危因素;高血糖可能与高尿酸血症有潜在的相关性。高尿酸血症的飞行员伴有不同程度的肾脏早期损伤。

     

    Abstract: Objective To analyse the prevalence of hyperuricemia (HUA) and its risk factors among male civil aviation pilots,and to examine the relationship between pilots' hyperuricemia and early renal injury.

    Methods The medical data of pilots accepting physical examination in Beijing Civial Aviation General Hospital in 2013 were analysed.Enzyme linked immunosorbent assay was applied to detect early renal injury indicators including urinary α1-microglobulin (α1-MG),β2-microglobulin (β2-MG),cystatin C (CysC),N-acetylglucosamine (NAG),retinol binding protein (RBP),and compared the differences of selected indicators in the pilots with or without HUA.

    Results A total of 97 out of 385 pilots (25.2%) were diagnosed with hyperuricuria.There was no significant difference in the HUA prevalence across age groups (P > 0.05).The results of logistic regression analysis showed the risk factors for hyperuricemia included high body mass index (BMI),hyperlipemia,and hyperbilirubinemia (P=0.001,0.004,and 0.009,respectively).Compared with the normouricemia group,the levels of urinary α1-MG,CysC,RBP,and NAG were significantly higher in the HUA group.

    Conclusion HUA is a severe metabolic disease in male civil aviation pilots.The prevalence of HUA is obviously higher in male civil aviation pilots than in general population or military pilots,and shows no age differences.High BMI,hyper lipemia,hyper bilirubinemia are the risk factors of HUA,while hyperglycemia may have a potential correlation with HUA.The pilots with HUA show varying degrees of early renal injurygroup

     

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