熊海燕, 高燕红, 斯依提, 蒋露芳, 汪千力, 居丽雯, 姜庆五. 上海某区儿童血清轮状病毒LLR型疫苗株的免疫水平[J]. 环境与职业医学, 2014, 31(5): 364-367. DOI: 10.13213/j.cnki.jeom.2014.0081
引用本文: 熊海燕, 高燕红, 斯依提, 蒋露芳, 汪千力, 居丽雯, 姜庆五. 上海某区儿童血清轮状病毒LLR型疫苗株的免疫水平[J]. 环境与职业医学, 2014, 31(5): 364-367. DOI: 10.13213/j.cnki.jeom.2014.0081
XIONG Hai-yan , GAO Yan-hong , SI Yi-ti , JIANG Lu-fang , WANG Qian-li , JU Li-wen , JIANG Qing-wu . Levels of Immunization to Rotavirus LLR Vaccine Strains among Children in a District of Shanghai[J]. Journal of Environmental and Occupational Medicine, 2014, 31(5): 364-367. DOI: 10.13213/j.cnki.jeom.2014.0081
Citation: XIONG Hai-yan , GAO Yan-hong , SI Yi-ti , JIANG Lu-fang , WANG Qian-li , JU Li-wen , JIANG Qing-wu . Levels of Immunization to Rotavirus LLR Vaccine Strains among Children in a District of Shanghai[J]. Journal of Environmental and Occupational Medicine, 2014, 31(5): 364-367. DOI: 10.13213/j.cnki.jeom.2014.0081

上海某区儿童血清轮状病毒LLR型疫苗株的免疫水平

Levels of Immunization to Rotavirus LLR Vaccine Strains among Children in a District of Shanghai

  • 摘要: 目的 了解2012年上海部分0~5周岁儿童的血清轮状病毒LLR型中和抗体水平及不同年龄段儿童轮状病毒感染的情况,为疫苗的研究提供科学数据。

    方法 在2012年6-8月上海市静安区儿保门诊部就诊的儿童中,筛选无发热、无轮状病毒感染疑似症状的健康儿童血清标本210份,采用微量中和试验方法检测儿童血清对轮状病毒LLR型疫苗株的中和抗体水平,并对检测结果进行统计学分析。

    结果 210份0~5周岁儿童血清中,轮状病毒LLR型中和抗体阳性率为27.1%,中和抗体几何平均滴度(GMT)为1:35.36; 0~6个月婴儿血清中和抗体阳性率为16.0%,GMT为1:28.72; 7~11个月儿童血清中和抗体阳性率为2.5%, GMT为1:25.88。1~2周岁儿童的中和抗体阳性率为20.0%, GMT为1:30.78, 2~3周岁儿童的中和抗体阳性率为20.0%, GMT为1:32.99,该两年龄组(段)间差异无统计学意义。3~4周岁儿童的中和抗体阳性率为56.67%, GMT为1:54.84, 4~5周岁儿童的中和抗体阳性率为63.33%, GMT为1:44.55,此两年龄组(段)儿童的阳性率和GMT均显著高于3周岁以下各年龄组,此两组间阳性率差异无统计学意义。

    结论 0~3周岁儿童中和抗体水平较低,特别是7~11个月年龄组为最低,提示可能为轮状病毒感染的高危儿童群体。

     

    Abstract: Objective To assess the levels of neutralizing antibodies to rotavirus LLR vaccine strains and the infection condition among children aged 0-5 years old in Shanghai, 2012, in the hope of providing the scientific basis for vaccine research.

    Methods The rotavirus LLR antibody was detected by neutralization test on the sera specimens of 210 healthy children who visited a child health clinic in Shanghai Jing'an District from June to August 2012. The obtained data were analyzed by statistical methods.

    Results The positive rate of rotavirus LLR antibody among the 210 sera specimens was 27.1%, and the geometric mean titer (GMT) of LLR specific neutralizing antibody was 1:35.36. To be specific, the positive rate of rotavirus LLR antibody and the GMT were 16.0% and 1:28.72 for infants aged 0-6 months, 2.5% and 1:25.88 for children aged 7-11 months, 20.0% and 1:30.78 for children aged 1-2 years, 20.0% and 1:32.99 for children aged 2-3 years, 56.67% and 1:54.84 for children aged 3-4 years, 63.33% and 1:44.55 for children aged 4-5 years. There were no significant differences in the positive rate and the GMT between the 1-2 age group and the 2-3 age group. The 3-4 and the 4-5 age groups reported higher positive rates and GMTs than other age groups. Also, the 3-4 and the 4-5 age groups showed no differences in the positive rate.

    Conclusion The level of neutralizing antibodies to LLR strains is low in the children of 0-3 years old, particularly in those aged 7-11 months, indicating that they may be the high-risk population of rotavirus.

     

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