孙真真, 张展, 王守林. 核受体与microRNA对细胞色素P450酶调控的分子机制[J]. 环境与职业医学, 2014, 31(3): 229-233. DOI: 10.13213/j.cnki.jeom.2014.0056
引用本文: 孙真真, 张展, 王守林. 核受体与microRNA对细胞色素P450酶调控的分子机制[J]. 环境与职业医学, 2014, 31(3): 229-233. DOI: 10.13213/j.cnki.jeom.2014.0056
SUN Zhen-zhen , ZHANG Zhan , WANG Shou-lin . Molecular Mechanisms of Nuclear Receptors and MicroRNA in Regulation of Cytochrome P450[J]. Journal of Environmental and Occupational Medicine, 2014, 31(3): 229-233. DOI: 10.13213/j.cnki.jeom.2014.0056
Citation: SUN Zhen-zhen , ZHANG Zhan , WANG Shou-lin . Molecular Mechanisms of Nuclear Receptors and MicroRNA in Regulation of Cytochrome P450[J]. Journal of Environmental and Occupational Medicine, 2014, 31(3): 229-233. DOI: 10.13213/j.cnki.jeom.2014.0056

核受体与microRNA对细胞色素P450酶调控的分子机制

Molecular Mechanisms of Nuclear Receptors and MicroRNA in Regulation of Cytochrome P450

  • 摘要: 细胞色素P450(CYP450)是一类生物代谢酶,其在体内的表达及活性可受外源化学物的调控,已成为当前环境毒理学研究的热点。本文通过总结核受体/转录因子及microRNA在化学物调控CYP450酶表达和活性中的作用及分子机制,系统分析调控作用的类型及其介导因子,认为化学物与CYP450酶之间的调控与代谢存在交互作用关系,在其毒效应中发挥重要作用。从而为环境污染物的毒性评价、毒效应机制及风险评估提供有价值的线索。

     

    Abstract: Cytochrome P450(CYP450) is a family of metabolic enzymes,and their expression and activity can be regulated by xenobiotics,which lead to a major concern of environmental toxicology.This review systematically summarized the roles and molecular mechanisms of nuclear receptors/transcription factors and microRNA in xenobiotic-regulated expression and activity of CYP450 enzymes,and analyzed the types of regulation and their intermediate factors.Furthermore,it was concluded that there existed an interaction between xenobiotics and CYP450 enzymes through regulation and metabolism,which played an important role in the toxic effects of xenobiotics.This review may help to provide clues for toxicity evaluation,mechanism exploration,and risk assessment of environmental pollutants.

     

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