王文荣, 陈赟, 丁春光, 李涛, 王焕强. 镍及其化合物致癌研究的文献计量和可视化分析[J]. 环境与职业医学, 2022, 39(11): 1291-1297. DOI: 10.11836/JEOM22060
引用本文: 王文荣, 陈赟, 丁春光, 李涛, 王焕强. 镍及其化合物致癌研究的文献计量和可视化分析[J]. 环境与职业医学, 2022, 39(11): 1291-1297. DOI: 10.11836/JEOM22060
WANG Wenrong, CHEN YUN, DING Chunguang, LI TAO, WANG Huanqiang. A bibliometric and visual analysis of research on carcinogenesis of nickel and nickel compounds[J]. Journal of Environmental and Occupational Medicine, 2022, 39(11): 1291-1297. DOI: 10.11836/JEOM22060
Citation: WANG Wenrong, CHEN YUN, DING Chunguang, LI TAO, WANG Huanqiang. A bibliometric and visual analysis of research on carcinogenesis of nickel and nickel compounds[J]. Journal of Environmental and Occupational Medicine, 2022, 39(11): 1291-1297. DOI: 10.11836/JEOM22060

镍及其化合物致癌研究的文献计量和可视化分析

A bibliometric and visual analysis of research on carcinogenesis of nickel and nickel compounds

  • 摘要: 背景

    目前金属镍被归类为可能对人类致癌,镍化合物被归类为人类致癌物,可是其确切致癌机制尚未阐明。

    目的

    分析镍及其化合物致癌研究趋势及热点,为镍及其化合物致癌研究提供研究方向。

    方法

    选择国内外权威数据库万方数据库、中国知网、美国国家医学图书馆文献数据库查询系统PubMed、Elsevier生物医学和药理学文摘数据库(EMBASE)检索与镍及其化合物致癌研究相关的文献,采用文献计量学的方法,应用VOS viewer 1.6.17可视化分析软件构建图谱,对符合纳入标准的文献年度出版数量、研究机构分布、国家/地区分布、期刊分布和关键词等方面进行文献计量与可视化分析。

    结果

    通过检索共筛选出与镍及其化合物致癌研究相关的中文文献242篇,外文文献(语种包括英文、德文、日文等)878篇。检索到国内最早发表相关文献是在1974年,广州医科大学(包括广州医学院和广州医学院化学致癌研究所)是发表文献最多的机构(35篇),《工业卫生与职业病》发文为各类中文期刊之首(19篇)。检索到国际上最早发表的外文文献是在1950年;美国发表的文献量排名最高(304篇),中国列第二位(83篇);Cancer Research发文最多(40篇)。关键词共现分析显示,国内镍及其化合物致癌研究主要集中在镍冶炼烟尘、硫酸镍、氯化镍等镍及其化合物与DNA损伤、DNA甲基化、诱导人支气管上皮细胞转化等致癌机制方面;国际相关研究集中在镍及其化合物致癌的职业危险因素、发病率、死亡率等人群流行病学研究和组蛋白修饰、氧化应激、DNA损伤、细胞转化等致癌机制方面。

    结论

    研究表明,镍及其化合物致癌研究热点涉及有关DNA损伤、DNA甲基化、组蛋白修饰、氧化应激、诱导人类支气管上皮细胞转化等致癌机制研究和职业危险因素、发病率、死亡率等人群流行病学研究,我国镍及其化合物致癌研究领域的文献数量近年来有下降趋势。鉴于我国职业性接镍人群数量较多,今后应继续加大镍及其化合物致癌的研究力度。

     

    Abstract: Background

    Metallic nickel and nickel compounds are classified as possibly carcinogic and carninogic to humans respectively, but the exact carcinogenic mechanism has not been clarified.

    Objective

    To analyze the carcinogenic research trend and hotspots of nickel and nickel compounds, and provide research directions for this topic.

    Methods

    Literature search on the carcinogenesis of nickel and nickel compounds was conducted through authoritative databases at home and abroad: Wanfang, China National Knowledge Infrastructure, PubMed at the US National Library of Medicine, and Elsevier’s biomedical research database EMBASE. VOS viewer 1.6.17 visual analysis software was applied to perform the bibliometric analysis and present results with charts on annual number of publications, distribution of author’s affiliations, country/region distribution, journal distribution, and keywords of literature that meet a predetermined inclusion criteria.

    Results

    A total of 242 Chinese documents and 878 foreign documents (languages included English, German, and Japanese) related to the carcinogenic research of nickel and nickel compounds were found. In terms of Chinese articles, the earliest publication of relevant research was in 1974; Guangzhou Medical University (including Guangzhou Medical College and Institute of Chemical Carcinogenesis of Guangzhou Medical College) was the institution that published most articles in this field (35 articles); Industrial Health and Occupational Diseases was the journal that published the most articles (19 articles). In terms of foreign articles, the earliest publication was in 1950; the United States ranked the country having the highest number of published articles (304 articles), and China took the second place (83 articles); Cancer Research was the journal that published the most articles (40 articles). The keyword co-occurrence analysis showed that the domestic studies on the carcinogenesis of nickel and nickel compounds mainly focused on nickel smelting fume, nickel sulfate, nickel chloride, and other nickel and its compounds in association with DNA damage, DNA methylation, induction of human bronchial epithelial cell transformation, and other carcinogenic mechanisms. The international studies focused on population epidemiological studies on occupational risk factors, incidence, and mortality on carcinogenesis of nickel and nickel compounds, and studies on histone modification, oxidative stress, DNA damage, cell transformation, and other carcinogenic mechanisms.

    Conclusion

    Studies have shown that the hotspots of carcinogenic research on nickel and nickel compounds involved studies on carcinogenic mechanisms related to DNA damage, DNA methylation, histone modification, oxidative stress, and induction of human bronchial epithelial cell transformation, and population epidemiological studies on occupational risk factors, incidence, and mortality. In recent years, the number of published articles on the carcinogenesis of nickel and its compounds in China has been decreasing. In view of the large number of occupational nickel-exposed population in China, more efforts should be made to study the carcinogenesis of nickel and nickel compounds in the future.

     

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