杨丹蕾, 张振宁, 王成尘, 崔道雷, 邓志华, 向萍. 基于文献计量可视化分析阻燃剂健康危害的研究热点与前沿趋势[J]. 环境与职业医学, 2022, 39(4): 410-418. DOI: 10.11836/JEOM21250
引用本文: 杨丹蕾, 张振宁, 王成尘, 崔道雷, 邓志华, 向萍. 基于文献计量可视化分析阻燃剂健康危害的研究热点与前沿趋势[J]. 环境与职业医学, 2022, 39(4): 410-418. DOI: 10.11836/JEOM21250
YANG Danlei, ZHANG Zhenning, WANG Cheng-chen, CUI Daolei, DENG Zhihua, XIANG Ping. Research hotspots and frontier trends of flame retardants-induced adverse health effects on humans: A visualized bibliometric analysis[J]. Journal of Environmental and Occupational Medicine, 2022, 39(4): 410-418. DOI: 10.11836/JEOM21250
Citation: YANG Danlei, ZHANG Zhenning, WANG Cheng-chen, CUI Daolei, DENG Zhihua, XIANG Ping. Research hotspots and frontier trends of flame retardants-induced adverse health effects on humans: A visualized bibliometric analysis[J]. Journal of Environmental and Occupational Medicine, 2022, 39(4): 410-418. DOI: 10.11836/JEOM21250

基于文献计量可视化分析阻燃剂健康危害的研究热点与前沿趋势

Research hotspots and frontier trends of flame retardants-induced adverse health effects on humans: A visualized bibliometric analysis

  • 摘要: 背景 阻燃剂是一类具有生态风险的新型环境污染物,其毒理效应明显并具有一定的环境持久性。近年来,由于阻燃剂在室内环境和人体组织中被广泛检出,其人群暴露的健康危害受到了广泛关注。

    目的 系统了解国际范围内阻燃剂的毒性效应及其对人体健康影响研究领域的主题演进、研究现状、研究进展及发展态势。

    方法 通过检索2000—2020年间Web of Science核心合集数据库中有关阻燃剂毒性效应及其对人体健康影响的文献,结合Endnote软件对文献进行筛选处理后进行历年发文量分析、重要引文及作者分析等,并利用文献计量可视化软件CiteSpace和VOSviewer绘制文献共被引图、关键词共现图、关键词聚类图、关键词时区图等图谱,并对相关数据进行分析。

    结果 2000—2020年间,阻燃剂毒性效应及其对人体健康影响研究方面的国际发文量共472篇,发文量随着年份的变化主要分为3个阶段,其中2001—2006年为萌芽探索阶段,关于阻燃剂的毒性效应研究刚刚起步;2007—2015年为成长阶段,研究学者们开始对阻燃剂致人体健康的危害进行风险评估;2016年至今为加速增长阶段,研究重心转变为阻燃剂对人体健康危害损伤机制的研究。我国在该领域的发文量(177篇)居世界第一,但中介中心性(反映学术影响力)仅为0.19,远低于荷兰(0.78)、英国(0.51)、德国(0.44)等欧美国家。在发文量排名前10的研究机构中,中国科学院以发文49篇位居榜首。Van der Veen等研究学者在磷系阻燃剂的毒性效应研究方面具有较强的影响,其在2012年发表的文献共被引达1319次,并在文献共被引图中处于最显著节点位置。阻燃剂对人体健康危害研究的文献高频关键词依次为多溴联苯醚(出现频次217次)、溴系阻燃剂(166次)、毒性(147次)、阻燃剂(102次),以及暴露、多氯联苯、体外实验、塑化剂等。通过关键词聚类及共现分析发现,目前研究正从污染源—暴露途径—污染物最终受体这一整体出发,系统探究阻燃剂的毒性机制,对人体在不同暴露途径下的环境健康风险进行评估。后续研究将深化阻燃剂毒性导致人体不同器官来源细胞损伤的机制研究,明确发生变化的关键因子及其内在关联,为阻燃剂健康危害的针对性预防提供依据。

    结论 阻燃剂毒性效应及其对人体健康影响的研究热点随时间发展而改变,且研究广度和深度不断加强;溴系/磷系阻燃剂的毒性效应始终是本领域研究的主流方向,后期研究热点将聚焦于阻燃剂造成的人体毒性分子机制研究。

     

    Abstract: Background As emerging environmental contaminants with ecological risks, flame retardants (FRs) exhibit obvious toxicity and persistence. In recent years, as FRs have been widely detected in indoor environments and human samples, the human health risks after FRs exposure are of great concern.

    Objective To systematically understand the topic evolution, research status, progress, and development trends on the toxicity and health effects of FRs on humans worldwide.

    Methods We retrieved the literature regarding toxicity of FRs and their effects on human health through the Web of Science database from 2000 to 2020, screened and processed the literature using Endnote software, and analyzed annual publications, important citations, and authors. CiteSpace and VOSviewer were employed to draw co-citation network, keyword co-occurrence network, and keyword clustering map for bibliometric visualization analysis.

    Results From 2000 to 2020, 472 international papers on toxic effects and human health impacts of FRs were published. In terms of publication years, FRs-related research was mainly divided into three stages: the infancy and exploration stage (2001—2006), when the research on the toxic effects of FRs was just starting; the growth stage (2007—2015), when the risk assessments of FRs on human health were conducted; and the acceleration stage (2016—), when the studies have shifted to the mechanism of FRs damage to human health. In this field, China published the largest number of published articles in the world (177 papers), but the intermediary centrality (reflecting academic influence) was only 0.19, far lower than that of European and American countries such as the Netherlands (0.78), Britain (0.51), and Germany (0.44). Among the top 10 research institutions in terms of the number of articles published, the Chinese Academy of Sciences topped the list with 49 articles. Van der Veen and other researchers had a strong influence on the research of the toxic effects of phosphorous FRs since their papers published in 2012 were cited 1319 times and in the most prominent node in the literature co-citation network. The high-frequency keywords in the literature on the human health effects of FRs were polybrominated diphenyl ethers (217 times), brominated FRs (166 times), toxicity (147 times), FRs (102 times), exposure, polychlorinated biphenyls, in vitro experiment, plasticizer, etc. Through keyword clustering and co-occurrence analyses, it was found that current research is systematically exploring the toxic mechanism of FRs from a perspective integrating pollution source-exposure route-final receptor of pollutants, and is evaluating the environmental health risks via different exposure routes. The visualized bibliometric analysis findings suggested that future studies understand the underlying mechanisms of various cell damage caused by FRs toxicity, identify the key factors of change and their relationships, aiming to provide a scientific basis for targeted prevention of health effects of FRs.

    Conclusion The research hotspots on the toxic effects of FRs and their effects on human health have changed over time, and the breadth and depth have been increasing. The toxic effects of brominated/phosphorus FRs have always been the mainstream direction in this field. Further studies will focus on the molecular mechanisms of human toxicity after FRs exposure.

     

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