Objective To examine the association between maternal smoking during pregnancy and prenatal gastroschisis, also to investigate the effects of different pregnancy phases and the amount of smoking per day on gastroschisis.
Methods Totally six studies published in Chinese and English literature databases were analyzed synthetically by Meta analysis through the Review Manager 4.2 and Stata software.
Results The combined effect value of odds ratio (OR) between smoking during pregnancy and gastroschisis was 2.3695% confidence interval (CI):2.02-2.76. The combined effect value of OR was 2.29 (95%CI:1.89-2.77) when the number of cigarettes smoked per day was between 10 to 20, and 2.54 (95%CI:1.68-3.85) when more than 20. There was no statistical significance of the OR value when cigarettes smoked less than 10 per day. The value of OR was 2.46 (95%CI:1.52-3.98) when women were smoking during the first three months of their pregnancy.
Conclusion Smoking in the first three months during pregnancy had significant correlation with prenatal gastroschisis, and this correlation in creased with the increasing daily smoking amount.
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