Objective To recognize the risk factors of severe cases of hand-foot-mouth disease(HFMD)in Shanghai, and to seek out clues for targeted interventions to prevent the occurrence of severe cases.
Methods A total of 73 severe cases and 146 mild cases of HFMD were enrolled according to the ratio of 1:2 in this matched case-control study. Relevant information was collected and analyzed by Cox regression model with univariate and multivariate respectively.
Results In terms of the environmental and behavioral factor, the risk of developing severe cases with additional children living together at same home and having history of respiratory tract infection within one month before onset was 2.08 and 3.66 times of mild cases respectively. In terms of the factors related to clinical feature, the risk of developing severe cases with fever duration of 1-2 days, more than 3 days and EV71 infection was 22.08, 142.63 and 15.16 times of mild cases respectively.
Conclusion It was concluded that having additional children living together at same home increased the chance of enterovirus infection. Fever duration and EV71 infection could be used as the initial indicators to identify severe cases.
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