Effects of exposure to bisphenol A during pregnancy on adverse pregnancy outcomes: A review of epidemiological studies

Bisphenol A (BPA) is an important environmental endocrine disruptor that can be absorbed by pregnant women through various pathways such as diet, drinking water, and skin contact. It can exert various biological activities such as estrogen-like and anti-androgen effects, which may affect pregnancy outcomes. The epidemiological studies related to BPA exposure during pregnancy and adverse pregnancy outcomes in recent years were reviewed in the paper, and inconsistent conclusions were identified. Some research conclusions suggested a correlation between BPA exposure during pregnancy and adverse pregnancy outcomes, including increased incidences of embryo implantation failure, recurrent spontaneous abortion, preterm birth, low birth weight infants, and dysplasia. Therefore, pregnant women should avoid or reduce BPA exposure during pregnancy, and order prenatal screening and prenatal diagnosis in the event of possible high-level BPA exposure. In order to develop better protective measures for pregnant women, the paper proposed conducting more epidemiological studies in the future to evaluate the correlation between BPA exposure during pregnancy and adverse pregnancy outcomes, to determine the safety threshold for BPA exposure, and to identify the best assessment method for BPA exposure.