Evaluation methods of skin damage under PM2.5 exposure: A review of recent studies
-
Abstract
As a representatve substance of current atmospheric pollutants in China, PM2.5 has a small partcle diameter and can penetrate through skin or mucosal tssues, which may cause damage to the respiratory system and cardiovascular and cerebrovascular system in human body. The skin is the largest organ of the integumentary system and the frst barrier to contact with pollutants such as PM2.5. Skin exposure to certain doses of pollutants may cause skin sensitzaton and aging. Considering that PM2.5 has different routes to cause damage to the skin and internal organs, appropriate experimental models are needed to study the mechanism of skin damage and the mechanism of drug repair under PM2.5 exposure. This artcle reviewed the paths of PM2.5 damage to the skin, and enumerated the existng methods for evaluatng skin damage under PM2.5 exposure as well as their principles and applicability. The evaluaton methods were classifed into in vivo and in vitro methods. The in vivo methods included mouse model evaluation and human exposure evaluaton (using smoke simulator); the in vitro methods included PM2.5 soluton exposure, dynamic inhalaton exposure, cell co-culture exposure model, and air-liquid interface cell exposure model, based on cell biology and toxicology. The artcle compared the advantages and disadvantages of above experimental methods, aiming to provide reference for the study of the damage mechanism of skin exposed to PM2.5.
-
-
DownLoad: