Functions and mechanisms of lncRNA in malignant tumors of female reproductive system
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Abstract
Long non-coding RNA (lncRNA) refers to an RNA transcript that is more than 200 nucleotides in length, has no typical open reading frame, and cannot encode a protein. It plays an important physiological role in biological processes such as transcription, translation, and RNA variability. It functions in the body by molecular guidance or as a molecular bait, molecular signal, and molecular scaffold. In recent years, a large number of studies have shown that lncRNA abnormal expression is closely related to female reproductive malignancies. Based on the latest research at home and abroad, we summarized the mechanisms of lncRNA in ovarian cancer, cervical cancer, and endometrial cancer, and briefly introduced the roles of lncRNA in other female reproductive malignancies such as endometrial cancer and vulvar cancer. It functions as an oncogene or tumor suppressor gene in cancer progression through various mechanisms. With the development of research methods and techniques, the potentials of lncRNA as a reliable biomarker and a new cancer therapeutic target will also be further developed, aiming to provide new ideas and methods to protect female reproductive health.
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