SU Chang, WANG Zhihong, BAI Jing, YANG Hui, WU Xiaofei, LIU Zhaomei, WANG Yingqi, WANG Huijun, ZHAGN Bing. Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China[J]. Journal of Environmental and Occupational Medicine, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004
Citation: SU Chang, WANG Zhihong, BAI Jing, YANG Hui, WU Xiaofei, LIU Zhaomei, WANG Yingqi, WANG Huijun, ZHAGN Bing. Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China[J]. Journal of Environmental and Occupational Medicine, 2021, 38(8): 810-816. DOI: 10.13213/j.cnki.jeom.2021.21004

Association between serum uric acid and depressive symptoms among people aged 55 years and above in four provinces of China

  • Background There are limited studies on the correlation between serum uric acid levels and depressive symptoms in middle-aged and elderly populations, and the study results are inconsistent.
    Objective This study is designed to investigate the association between serum uric acid levels and depressive symptoms in a middle-aged and elderly population.
    Methods Based on the 2018-2019 baseline data of the Community-based Cohort Study on Nervous System Diseases, a total of 10 212 people aged 55 years and above with complete demographic, lifestyle, depressive symptom score, and serum uric acid data were selected as study subjects. The Geriatric Depression Scale was used to evaluate whether the respondents had depressive symptoms, and fasting serum uric acid levels were tested at the same time. The positive rate of depressive symptoms and the prevalence rate of hyperuricemia in the population by different characteristics were calculated. The association between serum uric acid levels and depressive symptoms was analyzed using a multiple logistic regression model.
    Results The positive rate of depressive symptoms in the overall study population was 10.2%, 9.8% in men and 10.6% in women, respectively. The prevalence rate of hyperuricemia in the overall study population was 18.7%, 17.9% in men and 19.2% in women, respectively. The concentrations of serum uric acid in male and female were (341.6±89.4) and (296.2±79.8) μmol·L-1 respectively (P < 0.05). There was no significant difference in the positive rate of depressive symptoms between male (10.1%) and female (10.3%) with a normal serum uric acid level (P>0.05). The positive of depressive symptoms in male (8.7%) was significantly lower than that in female (11.6%) with an excessive serum uric acid level (P < 0.05). In participants without depressive symptoms, there was no significant difference in the prevalence rate of hyperuricemia in male (18.2%) and female (19.0%) (P>0.05). However, in participants with depressive symptoms, the prevalence rate of hyperuricemia in male (15.8%) was significantly lower than that in female (21.2%) (P < 0.05). The logistic regression analysis results showed that the risk of depressive symptoms in the highest quintile group of serum uric acid level was significantly lower than that in the lowest quintile group in male (OR=0.69, 95%CI: 0.49-0.98).
    Conclusion No gender difference in the positive rate of depressive symptoms is found in the population with a normal serum uric acid level, but women with an excessive serum uric acid level have a higher positive rate of depressive symptoms. There is a negative correlation between serum uric acid levels and depressive symptoms in the middle-aged and elderly male population.
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