YI Xiping, WEN Cong, HUANG Fei-yu, GUO Jian, YANG Fei. Epidemiologic advances in effects of microcystns exposure on human digestve system[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 879-883. DOI: 10.13213/j.cnki.jeom.2019.19100
Citation: YI Xiping, WEN Cong, HUANG Fei-yu, GUO Jian, YANG Fei. Epidemiologic advances in effects of microcystns exposure on human digestve system[J]. Journal of Environmental and Occupational Medicine, 2019, 36(9): 879-883. DOI: 10.13213/j.cnki.jeom.2019.19100

Epidemiologic advances in effects of microcystns exposure on human digestve system

  • The eutrophication in waters has led to frequent occurrence of cyanobacterial blooms. One of the main hazards of algal blooms is the production of microcystins (MCs). MCs are a class of most frequent, abundant, and toxic algal toxins detected in cyanobacterial blooms. They are chemically stable and difficult to remove, posing a serious threat to drinking water safety and human health. MCs can enter and accumulate in the body through various ways such as drinking water, diet, and recreational water, among which oral intake is the most important route for cyanobacterial toxin exposure. Afer ingeston into the digestve tract, MCs are absorbed and transported in the gastrointestnal tract, causing damage to the structure and functon of the gastrointestnal tract. Existng research shows that MCs play an important role in the development of digestve diseases. Acute exposure to water and food contaminated with MCs can cause gastrointestinal symptoms such as nausea, vomiting, and diarrhea. Low doses of chronic MCs exposure can cause gastroenterits and may even induce gastric and intestnal cancer. Most of the MCs afer gastrointestnal absorpton reach the liver through the portal vein system, leading to liver damage and liver cancer. Through summarizing the mechanisms about absorption and accumulation of MCs in the digestive system, and reviewing epidemiological studies on the effects of MCs on digestve diseases, especially gastrointestnal diseases, this paper provided an insight for further study on the relatonship between MCs and digestve diseases.

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