MEI Yue, WANG Wan-ping, LIU Jun, FAN Yi-gang, WANG Rui-xue, ZHANG Wei-hua, LIU Zhun, CHEN Dan. Case-control study on risk factors of esophageal cancer in residents in Danjiangkou City, Hubei Province[J]. Journal of Environmental and Occupational Medicine, 2019, 36(5): 445-451. DOI: 10.13213/j.cnki.jeom.2019.18854
Citation: MEI Yue, WANG Wan-ping, LIU Jun, FAN Yi-gang, WANG Rui-xue, ZHANG Wei-hua, LIU Zhun, CHEN Dan. Case-control study on risk factors of esophageal cancer in residents in Danjiangkou City, Hubei Province[J]. Journal of Environmental and Occupational Medicine, 2019, 36(5): 445-451. DOI: 10.13213/j.cnki.jeom.2019.18854

Case-control study on risk factors of esophageal cancer in residents in Danjiangkou City, Hubei Province

  • Background Esophageal cancer is a common malignant tumor of the digestive tract. The incidence and mortality of esophageal cancer in Chinese residents are at a high level in the world, which is extremely harmful to health. In Danjiangkou City, the incidence of esophageal cancer ranks first among all tumors and is higher than that in other areas of Hubei Province in recent years.

    Objective We aims to evaluate the prevalence and risk factors of esophageal cancer in Danjiangkou City of Hubei Province, and provide scientific data for adopting effective measures against esophageal cancer.

    Methods A total of 419 esophageal cancer incidents in 2015-2016 were collected from the Cancer Registry of the Danjiangkou City Center for Disease Control and Prevention, and eventually 351 patients were included in the study after removing the patients that were not contacted or did not complete the investigation on their own. According to sex and age of the patients, 351 healthy people with no esophageal cancer were matched as a control group. To explore the risk factors of esophageal cancer, trained investigators conducted a one-on-one interview with questionnaires. Chi-square test and conditional multivariate logistic regression analysis were used to determine the main risk factors of esophageal cancer in Danjiangkou City, and adjusted population attributable risk and synthesized population attributable risk of these factors were also calculated.

    Results The incidence rate of esophageal cancer in residents in Danjiangkou City in 2015-2016 was 45.25/100 000 person-years. Among the 419 registered cases, 67.78% were males, and 32.22% were females; 96.19% were >50 years old; 87.11% lived in rural areas and towns. The main risk factors of esophageal cancer in residents in Danjiangkou City were identified as adverse psychological status (OR=2.599, 95%CI:1.204-5.609), history of digestive diseases (OR=6.570, 95%CI:3.977-10.853), overeating habit (OR=2.379, 95%CI:1.033-5.477), eating salted food and sauerkraut at least 3 times a week (OR=2.011, 95%CI:1.111-3.639), and eating moldy food 1-2 times a week (OR=3.906, 95%CI:1.085-14.063). The adjusted population attributable risks of adverse psychological status, history of digestive diseases, overeating habit, eating salted food and sauerkraut, and eating moldy food were 12.59%, 50.64%, 11.86%, 27.77%, and 5.87% respectively. The synthesized population attributable risk for these risk factors was 70.42%.

    Conclusion Adverse psychological status, history of digestive disease, overeating habit, and preference for salted food, sauerkraut and moldy food may be the risk factors for esophageal cancer in residents in Danjiangkou City.

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