Review on effects of bisphenol A exposure in early life on neurodevelopment of offspring
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Abstract
Bisphenol A (BPA) is an important chemical in the manufacture of products such as engineering plastics, food containers, sports equipment, electronics, eyeglass lenses, dental composites, and sealants. Since the first production in 1992, China has shown rapid growth in the demand and production capacity of BPA, becoming the largest producer in the world. As an endocrine disrupting compound, BPA has been detected in most environment mediums and human body, and its impact of early life exposure on the neurodevelopment of offspring has caused worldwide concern. Animal experiments have demonstrated the biological possibility of adverse effects of BPA exposure on behavior and cognition, including hyperactive, invasive, and anxiety-like behaviors, as well as decreased spatial learning ability and memory ability. However, inconsistent conclusions are obtained in population-based epidemiologic studies, most of which suggest that early-life exposure to BPA is adversely associated with the development of neuroemotional behaviors and cognitive function in the offspring, such as anxiety, hyperactivity, depression, externalization, resistance, and somatic behaviors, as well as reduced working memory ability. Relevant research is scarce in China; therefore, further studies need to explore the impact and mechanism of BPA on children's neurodevelopment, aiming to develop better protective measures for vulnerable populations such as pregnant women and children.
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