FAN Yun, WANG Xu, XIA Yan-kai. Research progress on association between early-life exposure to phthalates and childhood obesity[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 141-150. DOI: 10.13213/j.cnki.jeom.2019.18647
Citation: FAN Yun, WANG Xu, XIA Yan-kai. Research progress on association between early-life exposure to phthalates and childhood obesity[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 141-150. DOI: 10.13213/j.cnki.jeom.2019.18647

Research progress on association between early-life exposure to phthalates and childhood obesity

  • Phthalates (PAEs) are environmental pollutants with teratogenicity, carcinogenicity, mutagenicity, and reproductive toxicity, which seriously affect human health. As one of the important industrial plasticizers, the adverse health effects linked to their extensive exposure, such as childhood overweight and obesity, have aroused wide concern. Exposure to environmental pollutants in the early stage of life may affect the developmental plasticity or developmental programming of fetuses and newborns, significantly increasing the sensitivity of children to environmental pollutants and even leading to the occurrence and deterioration of a series of related diseases in adulthood. This article introduced the current status of usage, exposure, and measurement of PAEs, the proposed mechanisms of harmful effects of PAEs, the causes and effects of PAEs exposure in early life, and the relationships between early-life PAEs exposure and childhood fat excess/obesity from the perspectives of epidemiological and animal studies and the underlying mechanism of action. At the same time, the article revealed the potential transgenerational genetic effects of PAEs exposure in early life on childhood obesity, pointed out the problems including exposure to chemical mixtures, exposure misclassification, confounders, and sexual dimorphism in current research and corresponding solutions, and prospected for future studies on reducing early-life PAEs exposure to prevent childhood obesity.

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