ZHU Hua-long, XIONG Yong-wei, WANG Hua. Adverse effects of cadmium on embryonic and fetal development and its mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639
Citation: ZHU Hua-long, XIONG Yong-wei, WANG Hua. Adverse effects of cadmium on embryonic and fetal development and its mechanism[J]. Journal of Environmental and Occupational Medicine, 2019, 36(2): 151-156. DOI: 10.13213/j.cnki.jeom.2019.18639

Adverse effects of cadmium on embryonic and fetal development and its mechanism

  • The adverse effects of cadmium on ecosystem and human health have attracted worldwide attention. Previous studies have focused mainly on the toxic effects of cadmium exposure in adulthood on liver, kidney, lung, brain, and testis; however, there are few studies on progeny and its long-term effects. Recently, the association between maternal cadmium exposure during pregnancy and embryonic/fetal dysplasia has become a hot topic in public health as a lot of studies have reported cadmium-induced developmental toxicity and its mechanism. Other studies have shown that maternal cadmium exposure during pregnancy can cause fetal death, fetal malformation, and fetal growth restriction. In addition, prenatal cadmium exposure can lead to lower IQ, mood disorders, cardiovascular diseases, male reproductive impairments, and other chronic diseases. The mechanisms of cadmium causing embryonic/fetal development injury mainly include maternal mechanism, placental mechanism, and fetal injury mechanism. Therefore, the adverse effects of cadmium on embryonic and fetal development and its mechanism were summarized in this review.

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